国内期刊药源性肺疾病文献的回顾性分析

目的:分析国内文献产生药源性肺疾病的药物种类及其因素。方法:通过CNKI查询2000-2009年国内期刊文献,对35篇文献中的72例产生药源性肺疾病的病例进行分析。结果:发生药源性肺疾病的病例的临床表现复杂多样,主要有肺结核、哮喘、肺动脉高压等,其中发生肺结核的例数最多为23例。共涉及19类药品,包括皮质激素、抗感染药物、心脑血管系统用药、解热镇痛药、生物制剂、中药制剂等。结论:警惕药物的肺损害,减少不良反应的发生,促进临床合理用药。

Retrospective analysis of drug-induced pulmonary diseases reported in domestic literatures

Objective:To find out the drugs that cause pulmonary diseases and the influencing factors.Methods:CNKI was searched for literatures on drug-induced pulmonary diseases between the years of 2000-2009.Senventy-two cases of drug-induced pulmonary diseases in 35 reports were classified and analyzed.Results:The drug-induced pulmonary disease cases had various clinical manifestations mainly including pulmonary tuberculosis,asthma,pulmonary hypertension and so on,among which pulmonary tuberculosis was the most frequently reported(23 cases).There were 19 kinds of drugs involved,including antibiotics,cardiovascular system drugs,anti-inflammatory drugs,biologics,Traditional Chinese Medicine preparations and so on.Conclusion:We should be vigilant against drug-induced pulmonary diseases and call for rational use of drugs.