| 高效液相色谱-质谱联用法研究乌头碱的水解产物* |
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| 引用本文： | 刘永刚,刘倩,张宏桂,乔延江.高效液相色谱-质谱联用法研究乌头碱的水解产物*[J].中国新药杂志,2007,16(4):303-305. |
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| 作者姓名： | 刘永刚 刘倩 张宏桂 乔延江 |
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| 作者单位： | 1. 吉林大学药学院,长春,130021
2. 北京中医药大学,北京,100029 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 目的：研究乌头碱的水解产物。方法：用高效液相色谱-电喷雾-质谱／质谱（HPLC—ESI—MS^N）的方法对乌头碱的水解产物进行分析，其中液相用梯度洗脱，质谱用正离子模式。结果：在水解液中发现了乌头碱的4种水解产物的准分子离子和其各级碎片，其准分子离子为604，500，586，482。结论：乌头碱的水解成分为乌头次碱，乌头原碱和另外2种未知产物。
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| 关 键 词： | 水解产物 乌头碱 高效液相色谱-质谱 |
| 文章编号： | 1003-3734（2007）04-0303-03 |
| 收稿时间： | 2006-09-10 |
| 修稿时间： | 2006-09-10 |
Studies on hydrolysates of aconitine by HPLC-MSn |
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| LIU Yong-gang,LIU Qian,ZHANG Hong-gui,QIAO Yan-jiang.Studies on hydrolysates of aconitine by HPLC-MSn[J].Chinese Journal of New Drugs,2007,16(4):303-305. |
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| Authors: | LIU Yong-gang LIU Qian ZHANG Hong-gui QIAO Yan-jiang |
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| Institution: | 1 Pharmacy College of Jilin University, Changchun 130021, China; 2 Beijing University of Traditional Chinese Medicine, Beijing 100029, China |
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| Abstract: | Objective:To analyze the hydrolysates of aconitine.Methods: The aconitine was eluated in a gradient setting by HPLC and then analyzed by ESI-MSn.Agilent MS TRAP equipped with ESI source was used as detector and operated in positive ion mode.Results:Four hydrolysates were found with protonated molecular ions at m/z 604,500,586 and 482.Conclusion:The hydrolysates were elucidated as bebziylaconine,aconine and other two unknown compounds. |
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| Keywords: | hydrolysate aconitine HPLC- MS^n |
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