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第三代抗组胺药地氯雷他定
引用本文:徐道华.第三代抗组胺药地氯雷他定[J].中国新药杂志,2005,14(12):1486-1488.
作者姓名:徐道华
作者单位:台州医药有限公司,台州,317700
摘    要:地氯雷他定是氯雷他定在体内主要的活性代谢产物,为一种口服非镇静抗组胺药.在美国和欧洲用于治疗过敏性鼻炎和慢性荨麻疹,起效快,不良反应小,尤其对儿童患者安全性好.对其药理作用、临床应用及安全性进行评价.

关 键 词:抗组胺药  地氯雷他定  过敏性鼻炎  慢性荨麻疹
文章编号:1003-3734(2005)12-1486-03
修稿时间:2005-06-22

The efficacy and safety of the third generation antihistamine desloratadine in clinical use
XU Dao-hua.The efficacy and safety of the third generation antihistamine desloratadine in clinical use[J].Chinese Journal of New Drugs,2005,14(12):1486-1488.
Authors:XU Dao-hua
Institution:Taizhou Medical Company Limitid, Taizhou 317700, China
Abstract:Desloratadine,the principal metabolite of loratadine,is itself an orally active, nonsedating,peripheral histamine H_1-receptor antagonist.It is indicated in the US and Europe for the treatment of allergic rhinitis(AR) and chronic idiopathic urticaria(CIU).It has a rapid onset of effect and efficacy throughout a 24 h dosage interval,as demonstrated in placebo-controlled trials.The overall incidence of adverse events in adults,adolescents and children was not significantly different to that with placebo.This article introduces the pharmacologics and the efficacy as well as the safety of desloratadine in clinical use.
Keywords:antihistamine  desloratadine  allergic rhinitls  chronic idiopathic urticaria
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