| 药物蛋白质组学研究进展 |
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| 引用本文： | 蒋宁,周文霞,张永祥. 药物蛋白质组学研究进展[J]. 中国新药杂志, 2005, 14(12): 1391-1394 |
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| 作者姓名： | 蒋宁 周文霞 张永祥 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 中国科学院资助项目，国家重点基础研究发展计划(973计划) |
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| 摘 要： | 药物蛋白质组学是基因组和药物发现之间的桥梁,目前已广泛应用于临床和生物医学的各个领域.其研究内容在临床前包括:构建分子药理筛选模型、筛选药物作用靶点、研究药物作用机制和毒理机制等;临床研究包括:利用疾病特异性蛋白质作为疾病分类分型和诊断的标志,还用于评价疗效和预测疾病的预后和转归等.
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| 关 键 词： | 药物蛋白质组学 分子药理筛选模型 药物作用靶点 药物作用机制 毒理机制 |
| 文章编号： | 1003-3734（2005）12-1391-04 |
| 修稿时间： | 2005-04-29 |
Pharmacoproteomics in drug development: current status and trends |
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| JIANG Ning,ZHOU Wen-xia,ZHANG Yong-xiang. Pharmacoproteomics in drug development: current status and trends[J]. Chinese Journal of New Drugs, 2005, 14(12): 1391-1394 |
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| Authors: | JIANG Ning ZHOU Wen-xia ZHANG Yong-xiang |
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| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | Pharmacoproteomics is the use of proteomic technologies in drug discovery and development. Along with pharmacogenomics and pharmacogenetics, pharmacoproteomics is taking on increased significance as the relevance of investigating and understanding protein expression in disease and drug development is appreciated. This review briefly addresses some of the various progresses and coming technologies, citing examples where these emerging approaches have been applied to pharmacology, toxicology and the development of drugs. |
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| Keywords: | pharmacoproteomics molecular pharmaceutical model drugtarget pharmaceutical and toxicological mechanism |
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