Phyllospongia属海绵次级代谢产物及其生物活性研究进展

Phyllospongia属海绵分布较为广泛,其次级代谢产物结构新颖多样,而且活性显著。从该属海绵中发现的次级代谢产物结构类型包括二倍半萜、呋喃萜、溴二苯醚、甾体、磺酸、核苷等类型化合物。其中,二倍半萜类化合物是该属海绵中最为典型的次级代谢产物,而且大多具有较强的生物活性,如细胞毒、抗菌、抗病毒、鱼毒、防附着等,在海绵的化学防御中发挥着重要作用。已有研究对从该属海绵乃至其他海绵中发现活性天然产物及药物先导化合物具有借鉴意义,文中对Phyllospongia属海绵中次级代谢产物的结构及其生物活性进行了简要综述。

Review on the secondary metatolites from Phyllospongia sponges and their bioactivities

The genus Phyllospongia is one of the most widespread sponges containing abundant secondary metatolites with novel structures and potent bioactivities.The main structure types of the secondary metatolites found in this genus include sesterterpenes,furanoterpenes,polybrominated diphenyl ethers,steriods,carteriosulfonic acids and nucleotides.Sesterterpenes are the most typical secondary metatolites isolated from this genus.Many of them exhibit various of bioactivities,such as cytotoxic,antibacterial,antiviral,ichthyotoxic and antifouling activities,and play important roles in the chemical defense of sponges.The previous research on the secondary metabolites from this genus provides an enlightenment to discover bioactive natural products and lead compounds from this genus and even other sponges,this paper reviewed the structures and bioactivities of the secondary metatolites from the sponges of genus Phyllospongia.