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双环醇的抗病毒与肝细胞保护作用及其作用机制
引用本文:刘耕陶.双环醇的抗病毒与肝细胞保护作用及其作用机制[J].中国新药杂志,2001,10(5):325-327.
作者姓名:刘耕陶
作者单位:中国医学科学院中国协和医科大学药物研究所,
摘    要:双环醇是人工合成的一类抗慢性病毒性肝炎新药,具有显著的保肝作用和一定抗肝炎病毒活性。该药50,100,200mg.kg^-1ig对CCl4,D-氨基半乳糖,对乙酰氨基酚引起的小鼠肝损伤以及卡介苗+脂多糖(LPS)诱导的小鼠免疫性肝炎均有明显降ALT和AST作用,并能减轻肝组织病理损伤。双环醇体外药对2.2.15细胞株分泌HBeAg和HBsAg有抑制作用,该药0.4和0.6g.kg^-1ig对鸭病毒性肝炎血清和肝脏的DHBV-DNA有显著抑制作用,对该药作用的机制进行多方面的研究的结果表明,双环醇不是转氨酶抑制剂,而是有清除自由基作用以保护细胞膜,并且能保护肝细胞核DNA免受损伤和减少细胞凋亡的发生。

关 键 词:双环醇  肝损伤  肝炎病毒  药理学研究
文章编号:1003-3734(2001)05-0325-03

The anti-virus and hepatoprotective effect of bicyclol and its mechanism of action
LIU Geng-tao.The anti-virus and hepatoprotective effect of bicyclol and its mechanism of action[J].Chinese Journal of New Drugs,2001,10(5):325-327.
Authors:LIU Geng-tao
Abstract:Bicyclol is a synthetic novel anti-hepatitis drug.It has remarkable hepatoprotective and certain anti-hepatitis virus actions.Oral administration of 50,100,200 mg*kg-1 bicyclol protected livers of mice from damage induced by CCl4,D-galactosamine,acetoaminophen and B.C.G.plus lipopolysacharides (LPS) expressed in decreases of ALT and AST as well as morphological damage of liver tissues.Addition of bicyclol to the cultivated 2.2.15 cell line inhibited secretion of HBeAg and HBsAg as well as HBV-DNA level.The results of mechanistic study on bicyclol indicated that bicyclol is not an inhibitor of transaminase,but a cell membrane protector through elinmination of free radicals.Moreover,bicyclol can protect hepatocyte nuclear DNA from damage and reduce the apoptosis induced by immuno-stimulating compound Con A.
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