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| MDR逆转活性紫杉烷类化合物的合成 | |
| 引用本文： | 张树军,沈敬山,王金兰,嵇汝运,安東政義. MDR逆转活性紫杉烷类化合物的合成[J]. 中国新药杂志, 2005, 14(5): 579-581 |
| 作者姓名： | 张树军 沈敬山 王金兰 嵇汝运 安東政義 |
| 作者单位： | 1. 中国科学院上海药物研究所,上海,201203;齐齐哈尔大学化学化工学院,齐齐哈尔,161006 2. 中国科学院上海药物研究所,上海,201203 3. 齐齐哈尔大学化学化工学院,齐齐哈尔,161006 4. 日本新潟大学工学部,新潟,950-2181 |
| 基金项目： | 王宽诚教育基金，上海市博士后科研项目 |
| 摘 要： | 目的:合成天然产物taxinine NN-3和taxinine NN-14,研究其对肿瘤细胞的多药耐药逆转活性.方法:以紫杉宁为出发原料,通过选择性水解9,10位的乙酰氧基,制成原乙酸酯后再水解.结果:以紫杉宁为原料经过3步反应,可以同时获得taxinine NN-3,taxinine NN-4两种天然产物,其中taxinine NN-3的收率为25%,taxinineNN-4的收率为68%.结论:高收率地合成了taxinine NN-3和taxinine NN-14. |
| 关 键 词： | 紫杉宁 MDR逆转活性 |
| 文章编号： | 1003-3734(2005)05-0579-03 |
Synthesis of taxoids against multidrug resistant tumor cells |
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| ZHANG Shu-jun,SHEN Jing-shan,WANG Jin-Lan,JI Ru-yun,ANDO Masayoshi. Synthesis of taxoids against multidrug resistant tumor cells[J]. Chinese Journal of New Drugs, 2005, 14(5): 579-581 | |
| Authors: | ZHANG Shu-jun SHEN Jing-shan WANG Jin-Lan JI Ru-yun ANDO Masayoshi |
| Abstract: | Objective:To synthesize taxinine NN-3 and taxinine NN-14 with biological activity against multidrug resistant (MDR) tumor cells. Methods: Starting from taxinine, taxinine NN-3 and taxinine NN-14 were synthesized via selective deacetoxylation, orthoester and hydrolysis. Results:Total yield of taxinine NN-14 was 68% and taxinine NN-4 was 25% from taxinine. Conclusion: A simple and yielding synthesis of taxinine NN-3 and taxinine NN-14 was achieved. |
| Keywords: | taxinine NN-3 taxinine NN-14 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |