| 罗格列酮的临床研究进展 |
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| 引用本文： | 贾鑫明,赵红兵,蔺怀明.罗格列酮的临床研究进展[J].药学服务与研究,2003,3(1):34-37. |
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| 作者姓名： | 贾鑫明 赵红兵 蔺怀明 |
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| 作者单位： | 1. 第二军医大学药学院药理学教研室,上海,200433
2. 乌鲁木齐军医学院药理学教研室,新疆呼图壁,831200 |
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| 摘 要： | 综述罗格列酮的临床研究进展及不良反应。通过对2型糖尿病病人的空腹血糖和糖基化血红蛋白HbA1c均值变化的比较，发现该药与其他抗糖尿病药联合用药优于单独用药，对只接受过饮食疗法的病人的效果优于接受过其他抗糖尿病药治疗的病人；另外，该药的不良反应轻微，对肝功能无明显影响。
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| 关 键 词： | 罗格列酮 临床研究 糖尿病 噻唑烷二酮类 不良反应 |
| 文章编号： | 1671-2838(2003)01-0034-04 |
| 修稿时间： | 2002年10月31 |
The progress of clinical study on rosiglitazone |
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| JIA Xin-Ming ,ZHAO Hong-Bing ,LIN Huai-Ming.The progress of clinical study on rosiglitazone[J].Pharmaceutical Care and Research,2003,3(1):34-37. |
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| Authors: | JIA Xin-Ming ZHAO Hong-Bing LIN Huai-Ming |
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| Institution: | JIA Xin-Ming 1,ZHAO Hong-Bing 2,LIN Huai-Ming 2 |
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| Abstract: | The progress of clinical study and adverse events of thiazolidine rosiglitazone were reviewed in this article. The clinical effect iveness of rosiglitazone in combination with other antidiabetic agents was better than that of rosiglitazone as monotherapy. Furthermore, the patients with type-2 diabetes mellitus administered with rosiglitazone, who had been previously treated with dietotherapy only, had better effect iveness than those who had been previously treated with one or more other antidiabetic agents. In addition, rosiglitazone has light adverse events and does not cause significant hepatic dysfunction. |
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| Keywords: | rosiglitazone thiazolidine diabetes mellitus type-2 |
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