| 帕金森病动物模型研究进展 |
| |
| 引用本文： | 张健,徐阿晶.帕金森病动物模型研究进展[J].药学服务与研究,2012,12(5):382-386. |
| |
| 作者姓名： | 张健 徐阿晶 |
| |
| 作者单位： | 上海交通大学医学院附属新华医院药学部,上海,200092 |
| |
| 基金项目： | 国家自然科学基金青年基金资助项目(No.30901312);上海市教委科研创新项目重点项目(No.12ZZ117);上海市高校选拔优秀青年教师项目;新华医院院基金资助项目(No.11YJ002) |
| |
| 摘 要： | 帕金森病是老年期常见的慢性退行性疾病,其发病机制尚未明了,目前尚无有效根治或者逆转病情的药物.为了更好地了解帕金森病的病理机制并寻求更有效的治疗药物,建立帕金森病相关动物模型至关重要.目前常见的帕金森病动物模型有神经毒素模型、转基因模型和基因敲除模型,本文对此做一综述.
|
| 关 键 词： | 帕金森病 动物模型 神经毒素 遗传基因 综述 |
Advances in research on animal models of Parkinson’s disease |
| |
| ZHANG Jian
,
XU AJing.Advances in research on animal models of Parkinson’s disease[J].Pharmaceutical Care and Research,2012,12(5):382-386. |
| |
| Authors: | ZHANG Jian XU AJing |
| |
| Institution: | *(Department of Pharmacy,Xinhua Hospital affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200433,China) |
| |
| Abstract: | Parkinson’s disease(PD) is a common chronic neurodegenerative disease of old people,the mechanism of which remains unclear,and there is no effective drug to completely cure or reverse the disease.It is very important to establish animal models for studying the pathogenesis of Parkinson’s disease and developing more effective drugs.Common animal models of Parkinson’s disease,such as the neurotoxin model,the transgene model and the gene knock-out model,are reviewed in this paper. |
| |
| Keywords: | Parkinson’s disease animal model neurotoxin genetic gene review |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
