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| 如意金黄散对长春瑞滨所致静脉炎的防治作用及其处方优化和剂型选择 | |
| 引用本文： | 马丽娟,周佳,牟金金,王学彬,辛海量,张莹,王卓.如意金黄散对长春瑞滨所致静脉炎的防治作用及其处方优化和剂型选择[J].药学服务与研究,2011,11(6):417-420. |
| 作者姓名： | 马丽娟 周佳 牟金金 王学彬 辛海量 张莹 王卓 |
| 作者单位： | 1. 第二军医大学长海医院药学部,上海200433;新乡医学院三全学院临床药理学教研室,河南新乡453003 2. 第二军医大学长海医院药学部,上海,200433 3. 第二军医大学长海医院药学部,上海200433;徐州医学院临床药学专业2010届本科生,江苏徐州221002 4. 第二军医大学长海医院中医医院,上海,200433 |
| 基金项目： | 国家自然科学基金项目(No.30973593); 上海市卫生局中医药科研基金课题(No.2010Y003A),上海市卫生局科研课题(No.2008055) |
| 摘 要： | 目的:探索对如意金黄散进行减方组合后,不同组方对长春瑞滨(用VIN表示)所致静脉炎的防治作用,同时考察其不同剂型的疗效.方法:用均匀设计法结合中药君臣佐使原理对如意金黄散进行拆方组合,以小鼠尾静脉注射VIN造模,以小鼠尾巴肿胀度为疗效指标,观察和比较各组静脉炎的发生、发展及转归情况.结果:大黄、姜黄、生天南星为主的糊剂(D组)、自制如意金黄散全方的糊剂(G组)、大黄、黄柏、厚朴为主的糊剂(F组)及其凝胶剂(F3组)、市售如意金黄散成方的糊剂(Ⅰ组)均显示有效,综合评价认为凝胶剂(F3组)最佳.结论:如意金黄散对VIN所致静脉炎有较明显的防治作用,不同处方及剂型效果有差异.有目的地简化处方可以改善疗效,并有利于针对临床需要进行剂型选择. |
| 关 键 词： | 长春瑞滨 静脉炎 如意金黄散 拆方 剂型 |
Effectiveness of Ruyijinhuangsan on phlebitis induced by vinorelbine and optimization of its formulations and selection of dosage forms |
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| MA LiJuan , ZHOU Jia , MU JinJin , WANG XueBin , XIN HaiLiang , ZHANG Ying , WANG Zhuo.Effectiveness of Ruyijinhuangsan on phlebitis induced by vinorelbine and optimization of its formulations and selection of dosage forms[J].Pharmaceutical Care and Research,2011,11(6):417-420. | |
| Authors: | MA LiJuan ZHOU Jia MU JinJin WANG XueBin XIN HaiLiang ZHANG Ying WANG Zhuo |
| Institution: | MA LiJuan1,2,ZHOU Jia1,MU JinJin1,3,WANG XueBin1,XIN HaiLiang4,ZHANG Ying1,WANG Zhuo1*(1.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China,2.Department of Clinical Pharmacology,School of Sanquan,Xinxiang Medical College,He'nan Xinxiang 453003,3.Undergraduate 2010 grade of Clinical Pharmacy,Xuzhou Medicine College,Jiangsu Xuzhou 221002,4.Department of Traditional Chinese Medicine,Shanghai 200433... |
| Abstract: | Objective: To investigate preventive and therapeutic effects of Ruyijinhuangsan on phlebitis induced by vinorelbine,select dosage forms and optimize the formulations.Methods: The phlebitis model of mice was established by injection of vinorelbine via tail vein.The occurrence and relief of tail swelling were as effectiveness index in mice.Different formulations by uniform designed based on traditional Chinese medical theory were examined in different groups.Results: Cataplasm group which consisted of rhubarb... |
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