多沙唑嗪治疗轻中度高血压的疗效及其对血浆内皮素和降钙素基因相关肽的影响

目的观察多沙唑嗪治疗轻、中度原发性高血压的疗效,探讨多沙唑嗪对血浆内皮素(ET)和降钙素基因相关肽(CGRP)的影响。方法采用随机、对照、双盲法,将轻、中度原发性高血压48例分为两组各24例,治疗组和对照组分别给予多沙唑嗪和特拉唑嗪,均为2mg,po,qd,共治疗8周。结果治疗组和对照组降血压有效率分别为835%,783%,差异无显著性(P>005)。治疗组总胆固醇亦明显下降(P<005)。两组治疗后ET浓度下降、CGRP水平升高。结论多沙唑嗪为一安全有效的降血压药物,在降血压的同时有降血脂作用;多沙唑嗪的降血压作用可能部分与其拮抗ET、升高CGRP的浓度有关。

Effect of Doxazosin on Blood Pressure, Plasma Calcitonin Gene-related Peptide and Endothelin Concentration in Patients with Mild to Moderate Essential Hypertension

Objective To observe the effect of doxazosin on blood pressure, plasma calcitonin gene-related peptide (CGRP) and endothelin (ET) concentration in patients with mild to moderate essential hypertension. Methods A randomized, double blind study was carried out on fourty-eight patients with stage 1 or stage 2 essential hypertension. The patients were randmised into doxazosin group and terazosin group. The levels of plasma ET and CGRP were dermined by radioimmunoassay methods before and after treatment. Results After 8 wk treatment, the effective rate of the blood-pressure control in doxazosin group and in terazosin group were 83.5% and 78.3%. No significant difference was found between the two groups ( P>0.05). TC levels in doxazosin group were lower significantly after the treatment than before treatment (P<0.05). The plasma ET for both experimental groups were significantly decreased (P<0.01) and plasma CGRP levels were significantly increased in both groups (P<0.01), and there was no significant difference between the two groups ( P>0.05). Conclusion Doxazosin is an effective antihypotension drug. It can also lower the plasma TC level. Its antihypertension effect may relate to the decreasing of plasma ET and the increasing of the plasma CGRP.