尼美舒利醇质体抗炎镇痛作用与皮肤刺激性研究

目的考察尼美舒利醇质体经皮给药的镇痛抗炎作用及皮肤刺激性。方法采用小鼠热板法和醋酸扭体法观察尼美舒利醇质体的止痛作用；建立大鼠佐剂性关节炎模型，观察尼美舒利醇质体对大鼠足肿胀及滑膜关节组织的影响；利用健康豚鼠观察尼美舒利醇质体皮肤刺激反应。结果与对照组比较，中、高剂量尼美舒利醇质体能明显提高小鼠自身的热痛阈值（P＜0.05）；并能使醋酸致小鼠扭体次数显著减少（P＜0.05）；抗炎实验结果表明，尼美舒利醇质体对佐剂引起的大鼠足肿胀关节炎有明显的抑制作用（P＜0.05）；尼美舒利醇质体对豚鼠无皮肤刺激作用。结论尼美舒利醇质体具有明显的抗炎、镇痛作用，且皮肤刺激性较小，是一种有效的经皮给药制剂。

Anti-inflammation,Analgesia and Skin Irritancy of Nimesulide Ethosomes

Objective To evaluate anti-inflammatory,analgesic effects and skin irritancy of nimesulide ethosomes. Methods The hot plate(acute plain model) and acetic acid induced stretching model were used to test analgesic effects of nimesulide ethosomes;a rat model of adjuvant arthritis was taken to study changes of paw swelling and the growth of synovial joint tissue by treatment of nimesulide ethosomes;and the healthy guinea pigs were used to investigate skin irritations caused by nimesulide ethosomes. Results Cons...