“肺与大肠相表里”理论指导治疗ALI/ARDS的临床疗效报告*

目的]观察"肺与大肠相表里"理论指导治疗急性肺损伤/急性呼吸窘迫统合征(ALI/ARDS)患者的临床疗效。方法]将42例ALI/ARDS患者随机分为治疗组和对照组,每组各21例。治疗组在西医常规治疗的基础上,加用自拟中药汤剂治疗;对照组仅给予西医常规治疗,均治疗7 d,比较两组疗效性指标。结果]两组治疗后临床疗效比较,P<0.05,两组临床疗效差异有统计学意义;28 d病死率比较,P>0.05,两组在28 d病死率方面差异无统计学意义;两组在临床症状方面组内、组间比较,均P<0.05,两组在改善症状方面均有统计学意义;两组实验室观察指标组间比较,均P<0.05,两组在改善病情方面均有统计学意义,但两组间比较,均P>0.05,两组差异无统计学意义。结论]以"肺与大肠相表里"理论为指导,中西医结合治疗ALI/ARDS的方案可有效缓解病情。

Clinical cases of treating ALI/ARDS guided by theory of the lung and the large intestine being exterior-interiorly related

Objective] To observe the clinical curative effects of treating ALI/ARDS guided by theory of "the lung and the large intestine being exterior-interiorly related".Methods] Forty-two patients with ALI/ARDS were randomly divided into treatment group and control group with 21 patients in each group.The patients in treatment group were treated by self-prescriped decoction except conventional therapy by Western medicine(WM),while the others in control group were received routine Western medicine only.All of them were treated for 7 days and after that the curative effect was compared between these two groups.Results] The comparison in clinical effect had significant difference(P<0.05) and the 28 days mortality between these two groups had no obvious difference(P >0.05);all the inter-group and intra-group comparison of clinical symptoms had significant differences(P<0.05).The mortality at 28 days had no significant difference.In respects of improving symptoms there was statistical difference in comparison of inter-group and intra-group(P<0.05).But the effect was better in treatment group than that of control group in the improving the difficulty of defecating in intra-group comparison(P=0.05),but it could not prove that there was no effect in control group in improving defecating.The comparison of laboratory indices between two groups had significant differences in improving pathologic condition of two groups(P<0.05),but the comparative result was no significant different between two groups(P>0.05).Conclusion] Under the guidance of the theory of "the lung and the large intestine being exterior-interiorly related" the comprehensive treatment with integrated TCM and WM in treating ALI/ARDS can effectively alleviate the pathologic condition.