黄柏中盐酸小檗碱的药代动力学研究

目的]测定黄柏中有效成分盐酸小檗碱在大鼠体内的药代动力学参数.方法]使用高效液相色谱(HPLC)检测黄柏中盐酸小檗碱在大鼠血浆中的血药浓度;并运用3p97程序对黄柏中盐酸小檗碱的药代动力学参数进行拟合.结果]黄柏中盐酸小檗碱在大鼠体内药代动力学参数是:血药浓度曲线下面积(AUC)=774.3(mg·L)/min肾排泄速度常数(Ke)=7.285×10-3L/min,吸收速度常数(Ka)=4.166×1012L/min,吸收半衰期T1/2(Ka)]=16.64min,肾排泄半衰期T1/2(Ke)]=95.15 min,出风时间T(peak)]=50.73 min,最大血药浓度C(max)]=3.898 mg/L.结论]黄柏中盐酸小檗碱在大鼠体内呈一室模型分布.

Pharmacokinetic study of berberine hydrochloride of cortex phellodendri in rat plasma

Objective] To study pharmacokinetics of berberine hydrochloride in Cortex Phel-lodendri in the rat.Methods] Use HPLC to determine serum concentrations of berberine hy-drochloride in Cortex Phellodendri in rat pLasma.The pharmacokinetic parameters of berberine hydrochloride was fitted with 3p97 procedure.Result] The pharmacokinetic parameters of berberine hydrochloride in Cortex Phellodendri were AUC=774.3 (mg·L)/min,Ke=7.285×10^-3 L/min, Ka=4.166×10^-2 L/min,T_1/2 (Ka)=16.64 min,T_1/2 (Ke)=95.15 min,T (peak)=50.73 min,C (max)=3.898 mg/L.Conclusion] The berberine hydrochloride in Cortex Phellodendri showed one-compartment in the body of Wistar rats.