附子-甘草药对配伍研究进展

中药配伍是中医用药的一大特色,合理的中药配伍可以达到减毒增效的效果。附子-甘草作为经典药对,已广泛应用于临床。文章通过综述近些年来中药药对附子-甘草的研究概况,并参考现代研究文献,从化学成分的相互作用(包括影响附子毒性成分的溶出)、与毒性成分形成沉淀或复合物、影响毒性成分在体内的吸收、分布、代谢、排泄等药代动力学过程以及配伍后对附子原有药效的影响几个方面阐释了附子-甘草配伍减毒存效的作用机制,并用中医药传统药性理论“四气五味”解释了附子-甘草配伍的科学内涵,以期以这一经典药对为切入点探讨中药配伍的意义。

Research progress on the herb pair combination of Glycyrrhizae Radix and Radix Aconiti Lateralis Preparata

Compatibility of traditional Chinese medicine is a feature of traditional Chinese medicine. Reasonable compatibility of traditional Chinese medicine can achieve the effect of reducing toxicity and increasing efficiency. Radix Aconiti Lateralis Praeparata and Glycyrrhizae Radix are considered as a classicherb-pair,which has been widely used clinically. In this paper,we summarizedthe basic overview of Glycyrrhizae Radix and Radix Aconiti Lateralis Preparata. Acccording to modern literature researches,we aimed to explain the mechanism of attenuating the effects of aconite and licorice from the interaction of chemical components including affecting the dissolution of toxic components in aconite and forming precipitates or complexes,and the pharmacokinetic processes of absorption,distribution,metabolism,excretion of toxic components in Radix Aconiti Lateralis Praepareta,as well as the changes in the efficacy of aconite after compatibility. We suggested to illustrate the scientificconnotation of the compatibility withthe theory of four qi and five flavor. Thepaper aimed to discuss the significance of compatibility of traditional Chinese medicine based on the classic herb-pair.