姜黄素固体脂质纳米粒制备及体外释放的研究

目的]以单硬脂酸甘油酯为载体材料制备姜黄素固体脂质纳米粒及其体外释放行为的研究。方法]采用乳化蒸发-低温固化法制备姜黄素固体脂质纳米粒,高速离心法测其包封率,激光粒径仪测定其粒径、电位,用差示扫描量热仪(DSC)表征其性质,采用透析法考察固体脂质纳米粒中姜黄素的体外释放行为。结果]姜黄素固体脂质纳米粒的平均粒径为(89.24±2.06)nm,Zeta电位为(-18.77±1.27)m V,药物平均包封率为(89.55±1.84)%,DSC结果表明其理化性质稳定可靠,体外12 h累计释放率为(43.12±1.02)%。结论]制备的姜黄素固体脂质纳米粒粒径小且分布均匀,具有良好的缓释作用。

Preparation and in vitro release of curcumin solid lipid nanoparticle

Objective] To prepare curcumin solid lipid nanoparticles (Cur-SLN) with glyceryl monostearate as its lipid matrix and study its in vitro release behavior.Methods] Emulsification-evaporation was used to prepare Cur-SLN and entrapment efficiency was measured by ultracentrifugation method.The properties including particle size and Zeta potential and physical property were measured by laser particle size analyzer and differential scanning calorimetry (DSC),respectively.In vitro release behavior was studied by diameter methods.Results] Mean diameter and Zeta potential of Cur-SLN were (89.24±2.06) nm and (-18.77±1.27) mV.The mean entrapment efficiency was (89.55±1.84)%.The physical property tested by the DSC was stability,and the in vitro accumulative release until 12 h was (43.12±1.02)%.Conclusion] Cur-SLN prepared in this study has small size which has an even distribution and satisfactory sustained release efficacy.