| 大黄酸对内毒素激活小胶质细胞的影响* |
| |
| 引用本文： | 景浩然,柴丽娟,郭虹,李美娇,刘青青,王少峡.大黄酸对内毒素激活小胶质细胞的影响*[J].天津中医药大学学报,2012,31(1):34-35. |
| |
| 作者姓名： | 景浩然 柴丽娟 郭虹 李美娇 刘青青 王少峡 |
| |
| 作者单位： | 300193 天津中医药大学中医药研究院,天津市中药药理学重点实验室,教育部方剂学重点实验室 |
| |
| 基金项目： | 国家自然科学基金青年项目,天津市卫生局科技基金 |
| |
| 摘 要： | 目的]旨在观察大黄酸对小胶质细胞细胞株的作用。方法]培养小胶质细胞细胞株,检测大黄酸对小胶质细胞活力及内毒素(LPS)诱导小胶质细胞一氧化氮(NO)产生的影响。结果]大黄酸可以在不影响细胞活力的情况下抑制NO在激活小胶质细胞中的产生。结论]大黄酸可以抑制LPS对小胶质细胞的激活。
|
| 关 键 词： | 大黄酸 小胶质细胞 炎性反应 |
| 收稿时间： | 2011/9/16 0:00:00 |
Effects of 1.8-Dihydroxy-3-carboxy-anthraquinone on LPS-induced microglial activation |
| |
| JING Hao-ran,CHAI Li-juan,GUO Hong,LI Mei-jiao,LIU Qing-qing and WANG Shao-xia.Effects of 1.8-Dihydroxy-3-carboxy-anthraquinone on LPS-induced microglial activation[J].Journal of Tianjin University of Traditonal Chinese Medicine,2012,31(1):34-35. |
| |
| Authors: | JING Hao-ran CHAI Li-juan GUO Hong LI Mei-jiao LIU Qing-qing and WANG Shao-xia |
| |
| Institution: | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China |
| |
| Abstract: | Objective] This study examined whether 1.8-Dihydroxy-3-carboxy-anthraquinone,a metabolite from Salvia miltiorrhiza,may exert an anti-inflammatory effect in microglia.Methods] We examined the effect of 1.8-Dihydroxy-3-carboxy-anthraquinone on cell viability and the production of nitric oxide (NO) induced by LPS treatment in rat primary cultured microglia.Results] 1.8-Dihydroxy-3-carboxy-anthraquinone could significantly inhibit the production of NO by LPS treatment in rat primary cultured microglia.Conclusion] 1.8-Dihydroxy-3-carboxy-anthraquinone can suppress microglial activation and this may be a mechanism underlying the neuroprotective activity of it. |
| |
| Keywords: | 1 8-Dihydroxy-3-carboxy-anthraquinone microglia inflammation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《天津中医药大学学报》浏览原始摘要信息 |
| 点击此处可从《天津中医药大学学报》下载免费的PDF全文 |
|
