| 药物肠道代谢研究方法进展 |
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| 引用本文： | 陈丽娜,刘亚男,任晓亮,戚爱棣.药物肠道代谢研究方法进展[J].天津中医药大学学报,2015,34(4):248-251. |
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| 作者姓名： | 陈丽娜 刘亚男 任晓亮 戚爱棣 |
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| 作者单位： | 天津中医药大学中药学院, 天津 300193,天津中医药大学中药学院, 天津 300193,天津中医药大学中药学院, 天津 300193,天津中医药大学中药学院, 天津 300193 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金(20111210110010)。 |
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| 摘 要： | 肠道是口服药物的必经通道, 肠道中不仅存在着影响药物吸收的转运体, 还含有许多与药物代谢相关的酶, 包括消化道上皮细胞存在的结合酶和消化道菌丛产生的酶, 这些酶不同程度的影响着药物在体内的存在形式、吸收过程等。因此, 胃肠道对药物的有关代谢作用日益受到重视, 其研究方法也不断改进。现就目前药物在肠道中代谢的研究方法及其特点进行综述。
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| 关 键 词： | 肠道代谢 体外法 在体法 体内法 |
| 收稿时间： | 2015/3/17 0:00:00 |
Progress of methods on drug intestinal metabolism |
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| CHEN Li-n,LIU Ya-nan,REN Xiao-liang and QI Ai-di.Progress of methods on drug intestinal metabolism[J].Journal of Tianjin University of Traditonal Chinese Medicine,2015,34(4):248-251. |
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| Authors: | CHEN Li-n LIU Ya-nan REN Xiao-liang and QI Ai-di |
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| Institution: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China and Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | Intestine not only has many transporters, but also expresses a range of metabolism enzymes, including the enzymes exist in gastrointestinal epithelial cells and digestive tract flora. These enzymes affect the form of the drug in the body and the absorption process and so on. Therefore, intestine first-pass metabolism of drugs is becoming more and more attention and the researching methods are improving. In this paper, the current methods of drug intestinal metabolism and their characteristics were reviewed. |
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| Keywords: | intestinal metabolism in vitro in situ in vivo |
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