皮肤外用制剂的流变学研究进展

皮肤外用制剂包括软膏剂、乳膏剂、凝胶剂、贴剂、贴膏剂等，为临床上的常用剂型之一，可避免首过效应，使用方便。流变学可描述产品的流动特性和力学性能，反映制剂的内部结构，已成为皮肤外用制剂的重要研究内容。流变学研究通常分为稳态流变学和动态流变学两种，用于研究样品的液体行为和固体行为。本文从两种流变学方法出发，综述了皮肤外用制剂的研究进展及常用的数据分析模型，以期为皮肤外用制剂的流变学研究提供参考。

Advances in rheological study of topical preparations for skin

Topical preparations for skin, including the commonly used dosage forms of ointments, creams, gels, patches and plasters, are convenient and can avoid the first-pass effect of drugs.Rheological study, which describes the flow characteristics and mechanical properties of products relevant to their Critical Quality Attributes, has become the main focus for topical preparations.Liquid and solid behaviors of products are usually investigated via steady rheology as well as dynamic rheology.This article reviews the research on topical preparations for skin and the data analysis models based on two rheological methods, aiming to provide some references for the rheological evaluation of topical preparations.