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| 布地奈德结肠定位微丸的制备及释药特性研究 | |
| 引用本文： | 刘云,张钧寿,胡林森.布地奈德结肠定位微丸的制备及释药特性研究[J].中国药科大学学报,2003,34(5):33-36. |
| 作者姓名： | 刘云 张钧寿 胡林森 |
| 作者单位： | 1. 江苏省人民医院临床药学研究室,南京,210029 2. 中国药科大学药剂学教研室,南京,210009 3. 上海信谊百路达药业有限公司,上海,200023 |
| 摘 要： | 目的：制备pH-时滞型布地奈德微丸并对其释药特性进行研究。方法：采用锅包衣法制备裁药微丸，并进行乙基纤维素有机溶液包衣及Eudragit FS30D水分散体包衣。用转篮法进行释放度实验，采用多种pH模式筛选和评价处方。结果与结论：包衣厚度及材料比和pH对释药速率均有影响。优选处方微丸在高低2种pH模式下，其释药特性符合设计要求。 |
| 关 键 词： | 布地奈德 结肠定位 微丸 pH-时滞型 |
| 文章编号： | 1000-5048(2003)05-0419-04 |
Study on the Preparation and Drug Release of Controled-Release Micropellets for Budesonide Colon Specific Delivery |
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| LIU Yun,ZHANG Jun-Shou,HU Lin-Seng.Study on the Preparation and Drug Release of Controled-Release Micropellets for Budesonide Colon Specific Delivery[J].Journal of China Pharmaceutical University,2003,34(5):33-36. | |
| Authors: | LIU Yun ZHANG Jun-Shou HU Lin-Seng |
| Institution: | LIU Yun 1,ZHANG Jun-Shou 2,HU Lin-Seng 3 1Department of Clinical Pharmacy,JiangSu Provincial Hospital,Nanjing 210029,China, 2 Department of Pharmaceutics,China Pharmacertical University,Nanjing 210009,China, 3 Shanghai Xinyi Bailuda Pharmaceutical Company,Shanghai 200023,China |
| Abstract: | AIM: The aim of the present study was to develop a pH-dependent and controled-release micropellets of budesonide and to evaluate their in vitro release. METHODS: The drug loaded pellets were prepared and then coated with organic solution of EC and an new enteric polymer(Eudragit FS 30D). Dissolution tests were carried out in media simulating pH conditions at various locations in the gastro-intestinal tract. RESULTS: Dissolution rate was affected by coat thickness, ratio of the two polymers and the pH of medium. Experiments mimicking the extremes of GI conditions indicated that about 70% of the drug would be released to the ileum and proximal colon region. CONCLUSION: The pellets showed an in vitro dissolution profile more appropriate to the pH profile of the ileum and colon.It is promising for the therapy of Crohn's desease . |
| Keywords: | Budesonide Colon specific pH-dependent Controlled-release Micropellets |
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