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盐酸雷尼替丁HPMC骨架片药物释放影响因素研究
引用本文:程紫骅,刘燕.盐酸雷尼替丁HPMC骨架片药物释放影响因素研究[J].中国药科大学学报,1998,29(4):35-37.
作者姓名:程紫骅  刘燕
作者单位:中国药科大学中昆药剂研究所
摘    要:用HPMC为骨架材料,用湿法制粒,将易溶于水的盐酸雷尼替丁制成缓释骨架片,考察HPMC的用量、粘度、湿润剂的浓度,压片压力、片剂大小和亲水性及疏水性辅料对盐酸雷尼替丁缓释骨架片体外释药速率的影响。结果表明盐酸雷尼替丁缓释片的体外释放行为均符合Higuchi方程。HPMC用量、压片压力、片剂大小对盐酸雷尼替丁缓释片的释放速率均有显著性影响;HPMC粘度和用不同浓度乙醇制粒对盐酸雷尼替丁的释放速率影响不明显;亲水性辅料乳糖、PVP-K30和疏水性辅料EC加入均对释药速率有较大影响,前者加快药物释放而后者减慢药物释放

关 键 词:盐酸雷尼替丁  HPMC  骨架片  释放

The Factors Influencing Ranitidine Hydrochloride Release from Hydroxypropylmethylcellulose Matrix Tablet
Cheng Zihu,Liu Yan,Zhu Jiabi Zhong Kun Institute of Pharmaceutics,China Pharmaceutical University,Nanjing.The Factors Influencing Ranitidine Hydrochloride Release from Hydroxypropylmethylcellulose Matrix Tablet[J].Journal of China Pharmaceutical University,1998,29(4):35-37.
Authors:Cheng Zihu  Liu Yan  Zhu Jiabi Zhong Kun Institute of Pharmaceutics  China Pharmaceutical University  Nanjing
Institution:Cheng Zihua,Liu Yan,Zhu Jiabi Zhong Kun Institute of Pharmaceutics,China Pharmaceutical University,Nanjing 210009
Abstract:The HPMC matrix tablet of soluble ranitidine hydrocloride(R) was compressed by wet method.Its effect of the amount and viscosity of HPMC,compressing pressure, tablet size and additives on release of the drug from matrix tablets was observed. The results showed that the release behavior of tablets followed Higuchi kinetics. The R release rate was decreased with increasing content of HPMC,tablet hardness and tablet size. The effect of viscosity of HPMC and alcohol content were not significant.The additives of hydrophilic lactose,PVP K 30 and lipophilic EC could affect the R release, and the former could increase the release of the matrix tablet and the later could slow the release.
Keywords:Ranitidine  HPMC  Matrix  tablet  Sustained release
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