| 格列吡嗪缓释片的制备及其释药特性的研究 |
| |
| 引用本文： | 孙国庆,徐坚.格列吡嗪缓释片的制备及其释药特性的研究[J].中国药科大学学报,1996,27(11):661-664. |
| |
| 作者姓名： | 孙国庆 徐坚 |
| |
| 作者单位： | 中国药材大学药剂学教研室 |
| |
| 摘 要： | 研究了羟丙甲纤维素（ＨＰＭＣ）水凝胶型格列吡嗪缓释片的制备及其释药特性。结果表明，药物从ＨＰＭＣ水凝胶骨架片中的释放符合零级动力学过程，其零级释药速率受到多种因素，如ＨＰＭＣ的型号、规格、用量，附加剂，制剂的大小与形状及压力的调节和控制。
|
| 关 键 词： | 格列吡嗪 水凝胶型缓释片 HPMC |
Studies on the Preparation and Release Characteristic of Glipizide Hydrophilic Gel Tablets |
| |
| Sun Guoqing,Xu Jian,Chen Qi,Zhao Cong.Studies on the Preparation and Release Characteristic of Glipizide Hydrophilic Gel Tablets[J].Journal of China Pharmaceutical University,1996,27(11):661-664. |
| |
| Authors: | Sun Guoqing Xu Jian Chen Qi Zhao Cong |
| |
| Abstract: | Glipizide hydrophilic gel tablets containing hydroxypropylmethyl-cellulos(HPMC) were prepared, and their drug release characteristic was also evaluated.The results indicated that the drug release process could be best described by zero-order kinetics mechanism.The zero-order release constant might be controlled or adjusted by some formulation and processing factors,such as:type and visocosity of HPMC,HPMC content,presence of additions,compressed force,shape and weight. |
| |
| Keywords: | Glipizide HPMC Hydrophilic matrices Release mechanism |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国药科大学学报》浏览原始摘要信息 |
| 点击此处可从《中国药科大学学报》下载免费的PDF全文 |
