夏天无中生物碱类化学成分的研究

对夏天无中的生物碱类化学成分进行系统研究。通过硅胶、RP-C₁₈、Sephadex LH-20柱色谱、重结晶、薄层色谱和高效液相色谱等技术，从夏天无块茎95%乙醇提取物中分离得到13个化合物，其结构运用现代波谱技术结合理化性质分别鉴定为:四氢巴马亭(1)，氧化北美黄连次碱(2)，doryanine(3)，巴马亭(4)，毕枯枯灵(5)，四氢小檗碱(6)，四氢黄连碱(7)，紫堇定(8)，epicorynoxidine(9)，N-methylcorydaldine(10)，(+)-corlumine(11)，N-methyl-6，7-dimethoxyisoquinolone(12)和氧化血根碱(13)。其中化合物2、3、6、7、9~13为首次从该植物中分离得到，化合物2、3、9~13 为首次从该属植物中分离得到。此外，药理实验表明，四氢巴马亭(1)可能具有镇痛或镇静的作用，毕枯枯灵(5)可能具有诱发癫痫的作用。

Alkaloid constituents from Corydalis decumbens

To study alkaloid constituents in Corydalis decumbens, thirteen compounds were isolated from 95% ethanol extracts of Corydalis decumbens(Thunb)Pers. by silica gel, RP-C₁₈, Sephadex LH-20 column chromatographer, recry stallization, thin-layer chromatography and HPLC. Their structures were elucidated on the basis of spectral data combined with physiochemical properties as tetrahydropalmatine(1), oxyhydrastinine(2), doryanine(3), palmatine(4), bicuculline(5), canadine(6), tetrahydrocoptisine(7), corydaldine(8), epicorynoxidine(9), N-methylcorydaldine(10), (+)-corlumine(11), N-methyl-6, 7-dimethoxyisoquinolone(12)and oxysanguinarine(13). Compounds 2, 3, 6, 7, and 9-13 were isolated from this plant for the first time. In addition, compounds 2, 3, and 9-13 were obtained firstly from this genus. Pharmacological experiments showed that tetrahydropalmatine(1)might have analgesic or sedative effects, and the bicuculline(5)could probably induce epilepsy.