| 靶向肿瘤相关成纤维细胞治疗策略的研究进展 |
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| 引用本文： | 蔡汉,刘艳红,殷婷婕,周建平,霍美蓉.靶向肿瘤相关成纤维细胞治疗策略的研究进展[J].中国药科大学学报,2018,49(1):20-25. |
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| 作者姓名： | 蔡汉 刘艳红 殷婷婕 周建平 霍美蓉 |
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| 作者单位： | 中国药科大学天然药物活性组分与药效国家重点实验室,中国药科大学天然药物活性组分与药效国家重点实验室,中国药科大学天然药物活性组分与药效国家重点实验室,中国药科大学天然药物活性组分与药效国家重点实验室,中国药科大学天然药物活性组分与药效国家重点实验室 |
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| 基金项目： | 国家自然科学基金资助项目(No.81703442) |
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| 摘 要： | 肿瘤相关成纤维细胞(TAFs)是肿瘤微环境(TME)中最主要的基质细胞，可通过旁分泌、直接的细胞-细胞接触、免疫调控和胞外基质重塑等方式，对肿瘤的发生、发展及转移产生重要影响，是目前广为关注的抗肿瘤新靶点。在分析TAFs在肿瘤的分布位置及独有的生物学表达基础上，对目前已报道的TAFs靶向制剂进行详细的综述和分析，以期为肿瘤的靶向治疗提供新的思路。
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| 关 键 词： | 肿瘤微环境 肿瘤相关成纤维细胞 酶激活式前药 纳米粒 TAFs靶向治疗 |
Advances in the targeted therapy of tumor-associated fibroblasts |
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| CAI Han,LIU Yanhong,YIN Tingjie,ZHOU Jianping and HUO Meirong.Advances in the targeted therapy of tumor-associated fibroblasts[J].Journal of China Pharmaceutical University,2018,49(1):20-25. |
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| Authors: | CAI Han LIU Yanhong YIN Tingjie ZHOU Jianping and HUO Meirong |
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| Abstract: | Tumor-associated fibroblasts(TAFs), the most important stromal cells of the tumor microenvironment(TME), have been found to support tumorigenesis and tumor metastasis in a variety of ways, including paracrine, direct contact with cells, immune regulation and extracellular matrix remolding. Therefore, TAFs in the TME have been an optimal target for cancer therapy. In this review, the TAFs targeted therapies are summarized to provide the new strategy for tumor treatments based on the analysis of the location and specific biological phenotypes of TAFs in tumors. |
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| Keywords: | tumor microenvironment tumor-associated fibroblasts enzyme-activated prodrugs nanoparticles TAFs targeted therapy |
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