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低分子肝素肺靶向微球的研究
引用本文:翟光喜,赵焰,谢宁昌,陈国广,韦萍,欧阳平凯.低分子肝素肺靶向微球的研究[J].中国药科大学学报,2001,32(2):18-21.
作者姓名:翟光喜  赵焰  谢宁昌  陈国广  韦萍  欧阳平凯
作者单位:1. 山东大学药学院,济南,250012
2. 南京工业大学制药与生命科学学院,南京,210009
摘    要:目的 考察低分子肝素肺靶向微球缓释性、稳定性和靶向性。方法 用乳化法制备微球,正交试验设计考察影响制备工艺的因素,体外释药试验研究其缓释性,以外观形态、粒度分布、包封率、释药性等的变化考察其稳定性,以及微球在家兔的体内分布。结果 所制备微球粒径在5-25μm者85.5%,包封率为87%,并有良好的缓释性、 靶向性和稳定性。结论 该法制备的微球稳定,可用于肺靶向研究。

关 键 词:低分子杆素  微球  明胶  制备  稳定性  靶向性
文章编号:1000-5048(2001)02-0098-06

Study on the Lung Targeting Gelatin Microspheres of Low Molecular Weight Heparin
ZHAI Guang-Xi,ZHAO Yan,XIE Ning-Chang,CHEN Guo-Guang,WEI Ping,OUYANG Ping-Kai Faculty of Pharmaceutical Sciences,Shandong University,Jinan,College of Pharmaceutics and Life Sciences,Nanjing University of Technology,Nanjin.Study on the Lung Targeting Gelatin Microspheres of Low Molecular Weight Heparin[J].Journal of China Pharmaceutical University,2001,32(2):18-21.
Authors:ZHAI Guang-Xi  ZHAO Yan  XIE Ning-Chang  CHEN Guo-Guang  WEI Ping  OUYANG Ping-Kai Faculty of Pharmaceutical Sciences  Shandong University  Jinan  College of Pharmaceutics and Life Sciences  Nanjing University of Technology  Nanjin
Institution:ZHAI Guang-Xi,ZHAO Yan,XIE Ning-Chang 1,CHEN Guo-Guang 1,WEI Ping 1,OUYANG Ping-Kai 1 Faculty of Pharmaceutical Sciences,Shandong University,Jinan 250012, 1College of Pharmaceutics and Life Sciences,Nanjing University of Technology,Nanjin
Abstract:AIM To test gelatin microspheres of low molecular weight heparin(LMWH-GMS) release behavior; lung target behavior and stability. METHODS The microspheres were prepared with the emulsifing method and some factors effecting the technology were analysed with the orthogonal test design. The sustained release of LMWH-GMS was studied in vitro and preliminary stability of LMWH-GMS was investigated by the changes of conformation, diameter distribution, encapsulated ratio and the drug delivery of LMWH-GMS. The lung target was tested preliminarily by the distribution in different tissues in rabbits. RESULTS LMWH-GMS had a significantly sustained release behavior, a good lung target and stability. CONCLUSION LMWH-GMS can be used for study of lung target.
Keywords:Low molecular weight heparin  Microsphere  Gelatin  Prepare
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