首页 | 本学科首页   官方微博 | 高级检索  
检索        

S1P信号通路:上皮细胞和内皮细胞屏障功能调控的新靶点
引用本文:梅慧芳,孙丽新,江振洲,张陆勇.S1P信号通路:上皮细胞和内皮细胞屏障功能调控的新靶点[J].中国药科大学学报,2016,47(6):654-660.
作者姓名:梅慧芳  孙丽新  江振洲  张陆勇
作者单位:中国药科大学江苏省新药筛选重点实验室;江苏省药效研究与评价服务中心,中国药科大学江苏省新药筛选重点实验室;药物质量与安全预警教育部重点实验室,江苏省药效研究与评价服务中心;药物质量与安全预警教育部重点实验室,中国药科大学江苏省新药筛选重点实验室;药物质量与安全预警教育部重点实验室
基金项目:国家自然科学基金重大国际(地区)合作研究项目(No.81320108029);国家自然科学基金资助项目(No.81274146);2015年度中医药行业科研专项资助项目(No.201507004-002)
摘    要:1-磷酸鞘氨醇(S1P)是一种具有多种生物活性的鞘脂类代谢产物,通过激活G蛋白偶联受体S1PRs调节重要的生理功能。S1P是维持上皮细胞和内皮细胞屏障功能重要的信号分子,S1P信号通路通过调节黏附连接和紧密连接组装、细胞骨架重排、黏着斑形成,发挥对屏障功能的调控作用,因此S1P信号通路可能成为改善急性肺损伤、炎症性肠病和败血症等疾病中屏障功能紊乱的新靶点。本文对S1P信号通路在上皮细胞和内皮细胞屏障功能调控中的作用及其在屏障功能破坏相关性疾病模型中的保护作用的研究进展进行综述,以期为开发治疗屏障功能破坏相关性疾病的新药提供理论参考。

关 键 词:S1P信号通路  上皮细胞屏障功能  内皮细胞屏障功能  急性肺损伤  炎症性肠病  败血症  FTY720

Sphingosine 1-phosphate signaling pathway:a novel target for regulation of epithelial and endothelial barrier function
MEI Huifang,SUN Lixin,JIANG Zhenzhou and ZHANG Luyong.Sphingosine 1-phosphate signaling pathway:a novel target for regulation of epithelial and endothelial barrier function[J].Journal of China Pharmaceutical University,2016,47(6):654-660.
Authors:MEI Huifang  SUN Lixin  JIANG Zhenzhou and ZHANG Luyong
Abstract:Sphingosine 1-phosphate(S1P)is a pleiotropic sphingolipid metabolite that has been shown to regulate important physiological function by activation of its G-protein-coupled receptors S1PRs. S1P has been identified as an important signaling molecule in maintaining epithelial and endothelial barrier function. S1P signaling pathway is involved in epithelial and endothelial barrier function by regulation of adherens junction and tight junction assembly, cytoskeletal reorganization, and focal adhesion formation. Thus, S1P signaling pathway may become a novel therapeutic target for cell barrier dysfunction during some illnesses such as acute lung injury, inflammatory bowel disease and sepsis. In this review, the research progress of S1P signaling pathway in regulating epithelial and endothelial barrier function and the application of S1P in barrier dysfunction-related diseases were summarized, so as to provide references for future research.
Keywords:S1P signaling pathway  epithelial barrier function  endothelial barrier function  acute lung injury  inflammatory bowel disease  sepsis  FTY720
点击此处可从《中国药科大学学报》浏览原始摘要信息
点击此处可从《中国药科大学学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号