| 铂类抗癌药物体内药物浓度的电热原子吸收光谱分析 |
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| 引用本文： | 顾萱,陈西敬,杨洁.铂类抗癌药物体内药物浓度的电热原子吸收光谱分析[J].中国药科大学学报,2000,31(3):55-59. |
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| 作者姓名： | 顾萱 陈西敬 杨洁 |
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| 作者单位： | [1]中国药科大学分析计算中心 [2]中国药科大学药理研究室 |
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| 摘 要： | 应用电热原子吸收光谱分析技术（ＥＡＡＳ）对血浆、尿液、胆汁及各种组织中的总铂的含量进行了测定。研究表明，经合理的原子化程序设定后，尿液和胆汁可以不加处理直接进样，血浆用０．２５％，ＴｒｉｔｏｎＸ－１００等量稀释，组织只采用简单快捷的均相酸消化法。本方法精密度ＲＳＤ〈１０％，回收率８７．４０％～１１０．０％，在０．０８～５．００μｇ／ｍｌ铂浓度范围一关系良好，相关系数ｒ〉０．９９６２适合于铂类药物药
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| 关 键 词： | 铂 原子吸收光谱 抗癌药 药物浓度 |
The Determination of Concentration in Body of Platinum-based Anti-Cancer Drugs by Electrothermal Atomic Absorption Spectroscopy |
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| GU XuanCHEN Xi-JingYANG JieLI Yue-Peng,ZHU Wen-Bin.The Determination of Concentration in Body of Platinum-based Anti-Cancer Drugs by Electrothermal Atomic Absorption Spectroscopy[J].Journal of China Pharmaceutical University,2000,31(3):55-59. |
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| Authors: | GU XuanCHEN Xi-JingYANG JieLI Yue-Peng ZHU Wen-Bin |
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| Institution: | GU Xuan
(Analytical Center)CHEN Xi-Jing
(Department of Pharmacology,China Pharmaceutical University,Nanjing 210009)YANG Jie
(Nanjing Lifenergy Science & Industry Co.LTD.210015)LI Yue-Peng
,ZHU Wen-Bin
(Analytical Center) |
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| Abstract: | The improved methods for the determination of total platinum in a large number of different tissuses and body fluids by electrothermal atomic absorption spectroscopy were described.Urine and bile were analyzed without pretreatment. Plasma was analyzed after adding one equivalent volume of 0.25% Triton X 100 aqueous solution. Tissues were analyzed with minimal pretreatment. The methods are precise and accurate and linear( r >0.9962) in the range. The sensitive and rapid methods of analysis are satisfied for the pharmacokinetics studies in animal receiving platinum. |
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| Keywords: | Platinum Atomic absorpotion spectroscopy Plasma Urine Bile Tissue |
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