| 缺血性脑卒中后小胶质细胞吞噬作用的研究进展 |
| |
| 引用本文： | 汪恒,孙浩,廖红.缺血性脑卒中后小胶质细胞吞噬作用的研究进展[J].中国药科大学学报,2023,54(4):399-409. |
| |
| 作者姓名： | 汪恒 孙浩 廖红 |
| |
| 作者单位： | 中国药科大学新药筛选中心 江苏省药效研究与评价服务中心，南京 210009,中国药科大学新药筛选中心 江苏省药效研究与评价服务中心，南京 210009,中国药科大学新药筛选中心 江苏省药效研究与评价服务中心，南京 210009 |
| |
| 基金项目： | 国家自然科学基金资助项目（No. 82073831） |
| |
| 摘 要： | 缺血性脑卒中是影响人类健康的重大疾病，目前有关它的病理机制并未完全阐明。小胶质细胞是中枢神经系统中重要的免疫细胞。缺血性脑卒中后，大量小胶质细胞激活，并向损伤区域迁移聚集，吞噬坏死的细胞或碎片，释放炎症因子或营养因子，参与了缺血性脑卒中的病理过程。其中小胶质细胞的吞噬作用在脑缺血损伤以及康复中发挥重要的作用。本文总结小胶质细胞吞噬作用的分子机制，并综述小胶质细胞吞噬作用在缺血性脑卒中的研究进展，探讨小胶质细胞吞噬作用在脑缺血损伤和康复中的多样性和复杂性，旨在为缺血性脑卒中的治疗和药物研发提供新的思路。
|
| 关 键 词： | 缺血性脑卒中 小胶质细胞 吞噬作用 |
| 收稿时间： | 2023/2/21 0:00:00 |
| 修稿时间： | 2023/5/14 0:00:00 |
Reaserch progress of microglial phagocytosis in ischemic stroke |
| |
| WANG Heng,SUN Hao and LIAO Hong.Reaserch progress of microglial phagocytosis in ischemic stroke[J].Journal of China Pharmaceutical University,2023,54(4):399-409. |
| |
| Authors: | WANG Heng SUN Hao and LIAO Hong |
| |
| Institution: | New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China,New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China,New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China |
| |
| Abstract: | Ischemic stroke is a major disease affecting human health, and its pathological mechanism has not been fully elucidated. Microglia are important immune cells in the central nervous system, and participate in the pathological process of ischemic stroke.Following an ischemic stroke, a surge in activated microglia occurs, migrating and congregating within the afflicted regions.These microglia engulf deceased cells or fragments, releasing inflammatory or nutritive factors, thereby participating in the pathogenesis of ischemic stroke.The phagocytosis of microglia plays an important role in cerebral ischemic injury and rehabilitation. This article summarizes the molecular mechanism of microglial phagocytosis and reviews the research progress of microglial phagocytosis in ischemic stroke, and discusses the diversity and complexity of microglial phagocytosis in cerebral ischemic injury and rehabilitation, so as to provide new ideas for the treatment and drug development of ischemic stroke. |
| |
| Keywords: | ischemic stroke microglia phagocytosis |
|
| 点击此处可从《中国药科大学学报》浏览原始摘要信息 |
| 点击此处可从《中国药科大学学报》下载免费的PDF全文 |
|
