| 无机纳米材料在药物递送中的研究进展 |
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| 引用本文： | 周叶舒,王燕梅,张倍源,吴帅聪,杨磊,尹莉芳.无机纳米材料在药物递送中的研究进展[J].中国药科大学学报,2020,51(4):394-405. |
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| 作者姓名： | 周叶舒 王燕梅 张倍源 吴帅聪 杨磊 尹莉芳 |
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| 作者单位： | 中国药科大学药学院药剂系，南京 210009,中国药科大学药学院药剂系，南京 210009,中国药科大学药学院药剂系，南京 210009,中国药科大学药学院药剂系，南京 210009,中国药科大学药学院药剂系，南京 210009,中国药科大学药学院药剂系，南京 210009 |
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| 基金项目： | 国家自然科学基金资助项目（No.81603051，No.81673377，No.81871477）；“重大新药创制”国家科技重大专项资助项目（No.2017ZX09101001-004）；江苏省自然科学基金资助项目（BK20160760，BK20170748）；重点高校基础研究基金资助项目（No.2016ZPY015）；江苏省“333”高层次人才培养计划 |
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| 摘 要： | 将药物、蛋白或基因高效且安全地递送到治疗部位一直是药学研究的热点。无机纳米材料以其良好的稳定性、优异的生物相容性以及较高的药物负载能力成为了药物递送系统的理想材料。本文从已报道的研究以及临床试验入手，对常用的无机纳米材料如碳纳米材料、二氧化硅纳米粒、钙纳米材料、金纳米粒、磁性纳米粒、上转换纳米粒和量子点在药物递送和临床转化方面的应用进行综述，为无机纳米药物递送载体在新药研发上的应用提供理论参考，对无机纳米材料进入临床应用进行了展望。
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| 关 键 词： | 无机材料 药物递送 临床转化 纳米技术 进展 |
| 收稿时间： | 2019/11/18 0:00:00 |
| 修稿时间： | 2020/6/23 0:00:00 |
Research progress of inorganic nanomaterials in drug delivery system |
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| ZHOU Yeshu,WANG Yanmei,ZHANG Beiyuan,WU Shuaicong,YANG Lei,YIN Lifang.Research progress of inorganic nanomaterials in drug delivery system[J].Journal of China Pharmaceutical University,2020,51(4):394-405. |
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| Authors: | ZHOU Yeshu WANG Yanmei ZHANG Beiyuan WU Shuaicong YANG Lei YIN Lifang |
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| Institution: | Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Efficient and safe delivery of drugs, proteins or genes to the targeted sites has been the focus of pharmaceutical research. Inorganic nanomaterials are ideal materials for drug delivery systems due to their good stability, excellent biocompatibility and high drug loading capacity.Inorganic nanomaterials are ideal materials for drug delivery systems due to their good stability, high biocompatibility and excellent drug loading capacity. In this review, we started with reported researches and clinical trials to discuss the researches and clinical transformation of these inorganic nanoparticles in application of drug delivery, including carbon nanomaterials, silica nanoparticles, calcium nanomaterials, gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and quantum dots, providing theoretical reference for application of inorganic drug delivery carriers in the development of new drugs, looking to the prospects of inorganic nanomaterials in clinical application. |
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| Keywords: | inorganic nanomaterials drug delivery clinical transformation nanotechnology advances |
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