锰超氧化物歧化酶基因TaqI多态性与精神分裂症有关联吗？

目的 探讨印度人群锰超氧化物歧化酶（ＭｎＳＯＤ／ＳＯＤ２）基因ＴａｑＩ多态性与精神分裂症的相互关系。方法 应用聚合酶链式反应（ＰＣＲ）和限制性片段长度多态性（ＲＦＬＰ）。方法 在６８例精神分裂症患者和６２例健康人群中观察了ＳＯＤ２基因多态性的分布。

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Objective To determine allelic association of the TaqI polymorphisms for the manganese superoxide dismutase (MnSOD; SOD 2) gene with schizophrenia in Indian. Methods SOD 2 gene allelic frequency and genotype were examined with the methods of the polymerase chain reaction (PCR) and restrictive fragment length polymorphism (RFLP) analysis in samples of 68 unrelated patients with schizophrenia and 62 unrelated population based case controls. Results TaqI digestion of the PCR fragments showed two ploymorphic sites named site A and site B. The frequencies of the two TaqI polymorphic sites did not show significant difference between the subjects. But schizophrenic patients showed excess B 2B 2 homozygotic genotype as compared with normal control subjects. Conclusion Whether or not allelic association of the TaqI polymorphism for SOD 2 gene is with schizophrenia needs to be replicated with an independent study to rule out a false positive result caused by the population structure.