| 4种附子配伍方给药后大鼠血浆中3个乌头类生物碱的药动学比较 |
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| 引用本文： | 何雷萍,狄 斌,杜迎翔,严 方,刘华清.4种附子配伍方给药后大鼠血浆中3个乌头类生物碱的药动学比较[J].中国药科大学学报,2010,41(1):55-59. |
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| 作者姓名： | 何雷萍 狄 斌 杜迎翔 严 方 刘华清 |
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| 作者单位： | 中国药科大学药物质量与安全预警教育部重点实验室;中国药科大学分析化学教研室; |
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| 摘 要： | 目的:研究大鼠灌胃给予含附子汤剂后乌头碱、新乌头碱和次乌头碱的药动学。方法:4组大鼠分别灌胃给予四逆汤(药液a)、附子水煎液(药液b)、附子加炙甘草水煎液(药液c)及附子加干姜水煎液(药液d),用LC-MS-MS方法测定大鼠血浆中乌头碱、新乌头碱和次乌头碱的浓度,采用DAS2.0计算药动学参数。结果:4种不同配伍方给药后,乌头碱、新乌头碱和次乌头碱的药动学参数有差异。与附子水煎液比,炙甘草与附子配伍,使乌头碱、新乌头碱和次乌头碱3个成分的tmax延迟,MRT0-t延长,且血药浓度-时间曲线出现多峰现象;由干姜及炙甘草配伍附子的四逆汤给药后tmax延迟,MRT0-t缩短。结论:药材配伍对相同成分的药动学行为有影响。
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| 关 键 词： | 乌头碱 新乌头碱 次乌头碱 药动学 |
Comparative pharmacokinetics of aconitine, mesaconitine and hypaconitine in rats after oral administration of four decoctions composed with Radix Aconiti Lateralis |
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| HE Lei-ping,DI Bin,DU Ying-xiang,YAN Fang,LIU Hua-qing Key Laboratory of Drug Quality Control , Pharmacovigilance,Ministry of Education.Comparative pharmacokinetics of aconitine, mesaconitine and hypaconitine in rats after oral administration of four decoctions composed with Radix Aconiti Lateralis[J].Journal of China Pharmaceutical University,2010,41(1):55-59. |
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| Authors: | HE Lei-ping DI Bin DU Ying-xiang YAN Fang LIU Hua-qing Key Laboratory of Drug Quality Control Pharmacovigilance Ministry of Education |
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| Institution: | HE Lei-ping1,2,DI Bin1,DU Ying-xiang1,YAN Fang1,LIU Hua-qing1 1Key Laboratory of Drug Quality Control , Pharmacovigilance,Ministry of Education,2Department of Analytical Chemistry,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Aim:To study pharmacokinetics of aconitine,mesaconitine and hypaconitine in rats after single oral administration of decoctions composed with Radix Aconiti Lateralis.Methods:Four groups of rats were orally administered four decoctions including decoction a(Sini decoction),decoction b(decoction composed with Radix Aconiti Lateralis),decoction c(decoction composed with Radix Aconiti Laterali and Radix et Rhizoma Glycyrrhizae Praeparata Cum Melle)and decoction d(decoction composed with Radix Aconiti Laterali a... |
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| Keywords: | aconitine mesaconitine hypaconitine pharmacokinetics |
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