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使用微粉化技术改善头孢呋新酯片的溶出
引用本文:柯学,平其能,朱颖.使用微粉化技术改善头孢呋新酯片的溶出[J].中国药科大学学报,2000,31(3):30-33.
作者姓名:柯学  平其能  朱颖
作者单位:柯学(中国药科大学药剂教研室,南京 210009)       平其能(中国药科大学药剂教研室,南京 210009)       朱颖(中国药科大学药剂教研室,南京 210009)
摘    要:为改善头孢呋新酯的溶出,采用气流粉碎球磨、重结晶、固态分散技术等多种微粉化技术,通过差热分析和X衍射研究微粉化后头孢呋新酯的晶型特征。结果表明,固态分散技术可使该药由晶型转变为无定型,从而大大增加其生剂的溶出。溶解热的计算进一步证明了这一结果。

关 键 词:头孢呋新酯  微粉化  气流粉碎  球磨  重结晶
修稿时间:2000-03-14

Dissolution Improvement of Cefuroxime Axetil Tablets by Using Micronization Technology
KE Xue,PING Qi-Neng,ZHU Ying.Dissolution Improvement of Cefuroxime Axetil Tablets by Using Micronization Technology[J].Journal of China Pharmaceutical University,2000,31(3):30-33.
Authors:KE Xue  PING Qi-Neng  ZHU Ying
Institution:KE Xue ,PING Qi-Neng ,ZHU Ying (Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009)
Abstract:In order to improve the dissolution of cefuroxime axetil, we used several types of micronization technology: air jet micronization, ball mill grinding, recrystallization, co precipitate. Crystal properties of cefuroxime axetil after micronization were studied by using DSC and X ray diffraction. The results indicated that co precipitation process might changed the crystal properties and improve the dissolution of cefuroxime axetil tablets. The results were further confirmed by the solubility heat of cefuroxime axetil in various states.
Keywords:Cefuroxime Axetil  Micronization  Air-jet micronization  Ball-mill grinding  Recrystallization  Co-precipitate
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