| 双环[1.1.1]戊烷衍生物的合成研究进展 |
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| 引用本文： | 黄雨,张寅生.双环[1.1.1]戊烷衍生物的合成研究进展[J].中国药科大学学报,2022,53(2):137-145. |
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| 作者姓名： | 黄雨 张寅生 |
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| 作者单位： | 正大天晴药业集团股份有限公司，江苏省抗病毒靶向药物研究重点实验室，南京 211100,正大天晴药业集团股份有限公司，江苏省抗病毒靶向药物研究重点实验室，南京 211100 |
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| 基金项目： | 江苏省抗病毒靶向药物研究重点实验室资助项目（［2019］No.1627） |
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| 摘 要： | 双环1.1.1]戊烷（BCP）是一种具有三维立体结构的桥环骨架，其作为苯环、叔丁基和炔烃的生物电子等排体，已经在药物化学领域得到广泛的应用。随着BCP应用范围的扩大，BCP及其衍生物的合成日益成为研究的热点。本文对BCP衍生物的主要合成策略和方法进行总结，旨在为新药研发人员提供参考。
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| 关 键 词： | 双环[1.1.1]戊烷 合成方法 进展 |
| 收稿时间： | 2021/11/1 0:00:00 |
| 修稿时间： | 2021/12/22 0:00:00 |
Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives |
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| HUANG Yu and ZHANG Yinsheng.Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives[J].Journal of China Pharmaceutical University,2022,53(2):137-145. |
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| Authors: | HUANG Yu and ZHANG Yinsheng |
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| Institution: | Jiangsu Key Laboratory of Targeted Antiviral Research, Chia Tai Tianqing Pharmaceutical Group, Nanjing 211100, China,Jiangsu Key Laboratory of Targeted Antiviral Research, Chia Tai Tianqing Pharmaceutical Group, Nanjing 211100, China |
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| Abstract: | Bicyclo 1.1.1] pentane (BCP) is a kind of bridged ring skeleton with a three-dimensional structure. As a bioisostere of benzene ring, tert-butyl and alkyne, it has been widely used in the field of medicinal chemistry.With the expansion of its application, the synthesis of BCP and its derivatives has become an increasingly attractive research hotspot for scientists.Based on this, the present article summarizes the main synthetic strategies and methods of BCP derivatives, in the hope of providing some reference for drug discovery researchers and some insight for new synthetic methods of such compounds. |
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| Keywords: | bcyclo [1 1 1] pentane (BCP) synthetic methods advances |
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