| 酸酐—酰亚胺共聚物的合成 |
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| 引用本文： | 蒋曙光,屠锡德,刘国杰,陈丹.酸酐—酰亚胺共聚物的合成[J].中国药科大学学报,2000,31(5):3-6. |
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| 作者姓名： | 蒋曙光 屠锡德 刘国杰 陈丹 |
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| 作者单位： | 中国药科大学药剂学教研室,南京 |
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| 摘 要： | 熔融缩聚法合成了酸酐－酰亚胺共聚物并研究了基性质。酸酐－酰亚胺共聚物是一种新型的生物可降解高分子材料，它是在以癸二酸（ＳＡ）和１，３－双（对羧基苯氧基）己烷（ＣＰＨ）为单体的聚酸酐骨架中插入含有酪氨酸的单体（ＴＭＡ－Ｔｙｒ）而形成的。酪氨酸作为免疫佐剂可显著提高机体对吸收抗原的免疫应答，从而使酸酐－酰亚胺共聚物有可能成为一种极佳的免疫抗原载体。
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| 关 键 词： | 聚酸酐 酸酐－酰亚胺 熔融缩聚法 合成 共聚物 |
Synthesis of Biodegradable Anhydride-co-imide Terpolymer |
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| JIANG Shu-Guang,TU Xi-De,LIU Guo-Jie.Synthesis of Biodegradable Anhydride-co-imide Terpolymer[J].Journal of China Pharmaceutical University,2000,31(5):3-6. |
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| Authors: | JIANG Shu-Guang TU Xi-De LIU Guo-Jie |
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| Institution: | JIANG Shu-Guang,TU Xi-De,LIU Guo-Jie Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | Polyanhydride composed of sebacic acid (SA), 1,3-bis( p -carboxyphenoxy)hexane (CPH) and N -trimellitylimido- L -tyrosine (TMA-Tyr) was synthesized by melt condensation polymerization. Tyrosine was incorporated into the polymer backbone due to its inherent ability to enhance the immune response to vaccine antigen. Polymers that had no crystalline regions were achieved. Polymers were characterized by 1HNMR and IR spectroscopy, thermal transition temperature analysis and gel permeation chromatography. |
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| Keywords: | Polyanhydride Anhydride-co-imide Condensation polymerization Synthesis |
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