中药结合厄贝沙坦治疗早期慢性肾衰竭并高血压的临床观察

目的观察中药肾衰方合高血压方结合厄贝沙坦治疗早期慢性肾衰竭(CRF)并高血压患者的疗效。方法早期CRF并高血压患者(Scrl35-450umol/L或Ccr30-50ml/min)62例,随机分为2组,治疗组(N=32)给予中药肾衰方合高血压方1剂/d,厄贝沙坦150-300mg,1次/d;对照组(N=30)给予厄贝沙坦150-300mg,1次/d,共12周。观察血压(BP)、24小时尿蛋白定量(UTP)、血甘油三脂(TG)、总胆固醇(CH),血尿素氮(BUN)、血清肌酐(Scr)等指标。结果两组患者治疗后BP、UTP、BUN、Scr等水平均比治疗前显著降低(P<0.01),观察组治疗后BP、UTP、BUN、Scr等指标水平明显低于对照组(P<0.05)。结论本方结合厄贝沙坦能更有效治疗CRF高血压,能更有效地降低患者UTP、BUN、Scr等指标,能改善和延缓CRF进展。

Treatment of early Chronic Renal Failure and High Blood pressure with integrated Traditional Chinese Medicine and Irbesartan

Objective To evaluate the efficacy of integrated the traditional Chinese Medicine shenshuai and gaoxieya(TCM-SG)with Irbesartan in treating patients with early chronic renal failure(CRF)and High Blood pressure.Methods 62patients with CRF and High Blood pressure were randomly divided in to treatment group and control group.Treatment group(32cases)were treated with the TCM-SG on the bases of western medicine treatment:Irbesartan150-300mg every day;control group(30cases)were treated with western medicine treatment only.The course of treatment was12weeks for both groups.The levels of blood pressure(BP),urinary total protein(UTP),triglyceride(TG),total cholesterol(TC),blood urea nitrogen(BUN)and serum creatinine(Scr)were observed.Results In both groups,the levels of BP,UTP,BUN and Scr were much lower than that before therapy(P<0.01).After treatment,the levels of BP,UTP,BUN and Scr of the treatment group were much lower than that of the control group(P<0.05).Conclusions The therapy integrated TCM-SG with lrbesartan can significantly reduce BP,UTP,BUN,Scr and improve renal function for patients with early CRF and High Blood pressure.