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N末端脑钠肽前体、淋巴细胞亚群与原发性高血压的相关性研究
引用本文:徐文莉,廖长征,陈思祖.N末端脑钠肽前体、淋巴细胞亚群与原发性高血压的相关性研究[J].海南医学,2014(23):3486-3488.
作者姓名:徐文莉  廖长征  陈思祖
作者单位:深圳市龙岗中心医院中心实验室,广东 深圳,518116
摘    要:目的探讨原发性高血压(EH)患者N末端脑钠肽前体(NT-pro BNP)及淋巴细胞亚群等指标变化情况。方法 328例高血压确诊患者按照分级标准进行分组,其中EH1级组115例,EH2级组109例,EH3级组104例;以120例同期健康体检者作为对照组。采用电化学发光免疫分析测定NT-pro BNP水平和流式细胞仪分析CD3^+、CD4^+、CD8^+、CD19^+水平,组间进行比较。结果高血压组血清中NT-pro BNP、CD4^+/CD8^+、CD19^+水平较健康对照组明显升高(P〈0.05),其中EH3级组升高最显著;CD3^+、CD4^+、CD8^+细胞明显低于正常对照组(P〈0.05),EH3级组降低最显著。NT-pro BNP水平与CD3^+、CD4^+、CD8^+等指标均呈显著负相关(r=-0.951,r=-0.973,r=-0.955;P均〈0.01),与CD19^+细胞(B细胞)、CD4^+/CD8^+呈显著正相关(r=0.934,r=0.98;P均〈0.01)。结论 EH患者的血压的临床分级与NT-pro BNP、CD3^+、CD4^+、CD8^+、CD19^+的水平密切相关,并可能参与EH的病理生理过程。

关 键 词:原发性高血压  N末端脑钠肽前体  淋巴细胞亚群

Relationship between N-terminal pro-brain natriuretic peptide,lymphocyte subpopulation and essential hypertension
XU Wen-li,LIAO Chang-zheng,CHEN Si-zu.Relationship between N-terminal pro-brain natriuretic peptide,lymphocyte subpopulation and essential hypertension[J].Hainan Medical Journal,2014(23):3486-3488.
Authors:XU Wen-li  LIAO Chang-zheng  CHEN Si-zu
Institution:. (Central Laboratory Shenzhen Longgang Center Hospital, Shertzhen 518116, Guangdong, CHINA)
Abstract:Objective To study the change of N-terminal pro-brain natriuretic peptide and lymphocyte subpopulation in essential hypertensive patients. Methods Totally 328 hypertensive patients were divided into three groups according to the standard of classification: grade 1 hypertensive(115 patients), grade 2 hypertensive(109 patients) and grade 3 hypertensive(104 patients). As the same time 120 normal controls were enrolled as control group.CD3^+、CD4^+、CD8^+、CD19^+level and serum NT-pro BNP concentration were measured by flow cytometry and electrochemiluminescence immunoassay(ECLIA). Results NT-pto BNP, CD4/CD8 and CD19^+levels in 328 patients with EH were significantly higher than those in the controls(P〈0.05) and they were increased with the increases of blood pressure, but CD3^+, CD4^+and CD8^+levels were significantly lower(P〈0.05) than the control and they were decreased with the increases of blood pressure. NT-pro BNP level was negatively correlated with CD3^+, CD4^+and CD8^+(r=-0.951,r=-0.973, r=-0.955; P〈0.01), and was positively correlated with CD19^+and CD4^+/CD8^+(r=0.934, r=0.98; P〈0.01).Conclusion NT-pro BNP, CD3^+, CD4^+, CD8^+and CD19^+were closely correlated with EH stage and probably involved in the pathophysiological process of EH.
Keywords:Essential hypertension  N-terminal pro-brain natriuretic peptide (NT-proBNP)  Lymphocyte sub-population
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