血清Gal-3与慢性心力衰竭的相关性及其临床意义

目的 探讨血清半乳糖凝集素-3(Gal-3)与慢性心力衰竭的相关性及其临床意义.方法 选取2014年2月至2016年2月因慢性心力衰竭于西安市第一医院心血管内科住院治疗的98例患者作为CHF组,选取同期在我院体检的86例健康者作为对照组.根据心衰程度将CHF组患者分为NYHA心功能Ⅱ级组31例、心功能Ⅲ级组35例和心功能Ⅳ级组32例.检测各组受检者的血清Gal-3、N末端脑钠肽前体(NT-proBNP)、左心室射血分数(LVEF)、超敏C反应蛋白(hs-CRP)、总胆固醇(TC)、尿素氮(BUN)以及甘油三酯,分析血清Gal-3与NT-proBNP、hs-CRP、LVEF、NYHA心功能分级的相关性.结果 ①CHF组患者和对照组的血清Gal-3(32.69±12.37)μg/L vs(14.59±10.33)μg/L]、NT-proBNP(2.64±0.47)pg/mL vs(1.18±0.39)pg/mL]和hs-CRP(6.39±2.75)mg/L vs(3.41±2.46)mg/L]水平比较,CHF组均高于对照组,差异均具有统计学意义(P<0.05);②心功能Ⅱ级组、Ⅲ级组和Ⅳ级组患者的血清Gal-3水平分别为(23.05±2.41)μg/L、(26.39±2.75)μg/L和(28.52±2.77)μg/L,血清Gal-3水平随着NYHA心功能分级的升高而显著升高,差异具有统计学意义(P<0.05);③血清Gal-3与NT-proBNP、hs-CRP水平呈正相关(r=0.957、0.787,P<0.05),与LVEF呈负相关(r=-0.631,P<0.05).结论 血清Gal-3与慢性心力衰竭具有相关性,对慢性心力衰竭具有良好的诊断效果,可以作为诊断慢性心力衰竭的生物学指标.

Correlation between serum Gal-3 and chronic heart failure and its clinical significance

Objective To investigate the correlation between serum galactose-3 (Gal-3) and chronic heart fail-ure and its clinical significance. Methods A total of 98 patients with chronic heart failure, who admitted to Department of Internal Medicine-Cardiovascula of the First Hospital of Xi'an from February 2014 to February 2016, were selected as the CHF group, and 86 healthy subjects were enrolled as the control group. According to the degree of heart failure, the CHF group was divided into New York Heart Association (NYHA) heart failure classⅡ(31 cases), NYHA heart failure classⅢgroup (35 cases), NYHA heart failure classⅣgroup (32 cases). The levels of serum Gal-3, N-terminal brain na-triuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), high sensitivity C-reactive protein (hs-CRP), to-tal cholesterol (TC), urea nitrogen BUN) and triglycerides were checked, and the correlation of serum Gal-3 with NT-proBNP, hs-CRP, LVEF, NYHA cardiac function were analyzed. Results ①The levels of serum Gal-3, NT-proB-NP, hs-CRP in the CHF group were (32.69±12.37)μg/L, (2.64±0.47) pg/mL, (6.39±2.75) mg/L, respectively, which were significantly higher than (14.59±10.33)μg/L, (1.18±0.39) pg/mL, (3.41±2.46) mg/L in the control group (P<0.05);②The serum Gal-3 level in the NYHA heart failure classⅡ, NYHA heart failure classⅢgroup, NYHA heart failure classⅣgroup were respectively (23.05±2.41)μg/L, (26.39±2.75)μg/L, (28.52±2.77)μg/L, and the serum Gal-3 levels increased significantly with the increase of NYHA cardiac function classification (P<0.05);③Correlation analysis showed that se-rum Gal-3 was positively correlated with the levels of NT-proBNP and hs-CRP (r=0.957, 0.787, P<0.05), and negatively correlated with LVEF (r=-0.631, P<0.05). Conclusion Serum Gal-3 is associated with chronic heart failure and has a good diagnostic effect on chronic heart failure, which can be used as a biological indicator for the diagnosis of chronic heart failure.