| 犬脑适应性再灌注的脑保护机制研究 |
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| 引用本文： | 陈辉清,甄云,麦明霞,陈绮坚,黄振林,胡少杰.犬脑适应性再灌注的脑保护机制研究[J].海南医学,2012,23(5):25-28. |
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| 作者姓名： | 陈辉清 甄云 麦明霞 陈绮坚 黄振林 胡少杰 |
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| 作者单位： | 陈辉清 (深圳宝安西乡人民医院,广东深圳,518102) ； 甄云 (深圳宝安西乡人民医院,广东深圳,518102) ； 麦明霞 (深圳宝安西乡人民医院,广东深圳,518102) ； 陈绮坚 (深圳宝安西乡人民医院,广东深圳,518102) ； 黄振林 (深圳宝安西乡人民医院,广东深圳,518102) ； 胡少杰 (深圳宝安西乡人民医院,广东深圳,518102) ； |
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| 基金项目： | 深圳市宝安区科技计划项目 |
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| 摘 要： | 目的探讨崭新的改善灌注的方法—适应性再灌注的脑保护作用。方法 21只犬被随机分为三组:对照组、常规再灌注组、适应性再灌注组,各7只。对犬的基本生命体征变化、血气指标、血清离子浓度进行实时同步监测分析,并对缺血脑组织学变化及神经功能进行评价。结果脑适应性再灌注对血气指标、电解质等的影响小,能明显改善再灌注区的损伤神经元的功能及病理。结论脑适应性再灌注是一种有效的脑保护作用的灌注方式。
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| 关 键 词： | 失血性休克 脑缺血 复苏 再灌注 神经功能评分 |
Study on the cerebral protection effect of cerebral adapted reperfusion in canine |
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| CHEN Hui-qing, ZENG Yun, MAI Ming-xia, CHEN Qi-jian, HUANG Zhen-lin, HU Shao-jie.Study on the cerebral protection effect of cerebral adapted reperfusion in canine[J].Hainan Medical Journal,2012,23(5):25-28. |
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| Authors: | CHEN Hui-qing ZENG Yun MAI Ming-xia CHEN Qi-jian HUANG Zhen-lin HU Shao-jie |
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| Institution: | . Xixiang People’s Hospital of Bao’an District of Shenzhen City, Shenzhen, 518102, Guangdong, CHINA |
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| Abstract: | Objective To investigate the cerebral protection effect of cerebral adapted reperfusion. Methods Twenty-one mongrel dogs were randomly divided into three groups: the control group, the routine reperfusion group, and the adapted reperfusion group, each with 7 cases. The basic vital signs, blood gas, and electrophysiological Changes were monitored and analyzed. The cerebral ischemic histology and neurological function were evaluated. Results The cerebral adapted reperfusion has less impact on blood gas and electrophysiological Changes, which was able to significantly improve the function of ischemic neurons and histologic damage. Conclusion Cerebral adapted reperfusion is a beneficial reperfusion style, which has neuroprotective effect. |
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| Keywords: | Hemorrhagic shock Cerebral ischemia Fluid resuscitation Reperfusion Neurological grade |
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