吸烟对男性糖尿病患者血脂代谢的影响

目的 探讨吸烟对男性糖尿病患者血脂代谢的影响.方法 选择男性糖尿病患者156例,按照吸烟情况分为不吸烟组、戒烟组、少量吸烟组(少量组)和大量吸烟组(大量组),询问患者糖尿病病史、吸烟(包括吸烟时间、每日吸烟支数、戒烟年限)、饮食及运动情况(每日运动时间和运动量),测量身高、体重、腰围、臀围和体脂分数等,检测血液中空腹血糖(FBG)、餐后2 h血糖(2 hPBG)以及甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)水平,采用协方差分析和多元逐步回归法分析吸烟对血脂的影响.结果 与不吸烟组比较,大量组TG水平明显较高(P<0.05);协方差分析表明,大量组HDL-C水平较不吸烟组显著降低(P<0.05),但TC、TG和LDL-C间比较差异均无统计学意义(P>0.05);与戒烟组比较,少量组HDL-C显著较低(P<0.05),大量组TG水平较高而HDL-C水平较低(P<0.05);协方差分析表明,大量组TG和HDL-C水平与戒烟组比较差异均具有统计学意义(P<0.05).吸烟与HDL-C间呈显著负相关性(P<0.05).结论 吸烟是男性糖尿病患者体内脂代谢紊乱的独立危险因素,戒烟对调节脂代谢具有重要意义.

Effects of smoking on blood lipid metabolism in male patients with diabetes mellitus

Objective To explore the effects of smoking on blood lipid metabolism in male patients with diabe-tes mellitus. Methods A total of 156 patients with diabetes mellitus were enrolled in the study, which were divided into no-smoking group, stop-smoking group, slight smoking group and heavy smoking group according to smoking status. The history of diabetes, smoking status (including time of smoking, daily amount of smoking, smoking cessation age), di-et and exercise situation (daily exercise time and amount of exercise) were asked. The height, weight, waist circumfer-ence, hip circumference and body fat percentage were measured. The levels of fasting blood glucose (FBG), postprandial 2 hours blood glucose (2 hPBG) and triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were detected. The effect of smoking on blood lipids was ana-lyzed by covariance analysis and multiple stepwise regression analysis. Results Compared with no-smoking group, the level of TG was significantly higher in heavy smoking group (P<0.05), while the level of HDL-C was decreased signifi-cantly (P<0.05), with no statistically significant difference in TC, TG and LDL-C between the two groups (P>0.05). Compared with stop-smoking group, the level of HDL-C in slight smoking group was significantly lower (P<0.05), and the level of TG was significantly higher and the level of HDL-C decreased significantly in heavy smoking group (P<0.05). There was significant negative relation between smoking and HDL-C (P<0.05). Conclusion Smoking is an inde-pendent risk factor for the metabolic disorder of lipid metabolism in male patients with diabetes mellitus. Stop-smoking has important significance for the regulation of lipid metabolism.