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2010年海南省人民医院细菌耐药性监测
引用本文:吴彪,吴华,符健,林锋,贾杰.2010年海南省人民医院细菌耐药性监测[J].海南医学,2012,23(17):96-99.
作者姓名:吴彪  吴华  符健  林锋  贾杰
作者单位:海南省人民医院感染科,海南海口,570311
基金项目:海南省自然基金项目(编号:310123)
摘    要:目的 了解2010年我院全年临床分离常见细菌对常用抗菌药物的耐药性现状.方法 采用纸片扩散法进行抗菌药物敏感试验,采用WHONET 5.4软件进行数据分析.结果 临床分离的1 634株细菌中,革兰阳性菌占25.5%,革兰阴性菌占74.5%.耐甲氧西林金黄色葡萄球菌检出率为34.2%,未发现耐万古霉素及利奈唑胺的葡萄球菌,大肠埃希菌和肺炎克雷伯菌中产超广谱β内酰胺酶(ESBLs)检出率各为39.5%和25.8%,肠杆菌科细菌均对碳青霉烯类敏感;其中铜绿假单胞菌对哌拉西林/他唑巴坦、美罗培南及左氧氟沙星的耐药率分别为22.8%、24.4%和27.7%.鲍曼不动杆菌对美罗培南、亚胺培南的耐药率为22.7%、54.5%.洋葱伯克霍尔德菌对左氧氟沙星、美罗培南和磺胺甲唑/甲氧苄啶的耐药率为2.3%、9.1%、9.1%.结论 我院2010年临床分离菌以革兰阴性菌为主,铜绿假单胞菌仍居第1位,肠杆菌科细菌对碳青霉烯类抗菌药物耐药率最低.定期进行细菌耐药性监测有助于了解医院细菌耐药性变迁,为临床经验用药提供依据.

关 键 词:细菌耐药性  抗菌药物  革兰阳性球菌  革兰阴性杆菌

Bacterial distribution and resistance in the People’s Hospital of Hainan Province in 2010.
WU Biao , WU Hua , FU Jian , LIN Feng , JIA Jie.Bacterial distribution and resistance in the People’s Hospital of Hainan Province in 2010.[J].Hainan Medical Journal,2012,23(17):96-99.
Authors:WU Biao  WU Hua  FU Jian  LIN Feng  JIA Jie
Institution:. Infectious Department, People’s Hospital of Hainan Province, Haikou 570311, Hainan, CHINA
Abstract:Objective To investigate the drug resistance of the clinical isolates from the People’s Hospital of Hainan Province in 2010. Methods The susceptibility testing was performed using K-B method. The results were analyzed by WHONET5.4. Results A total of 1 634 clinical isolates were obtained, of which 25.5% was Gram-positive cocci and 74.5% was Gram-negative bacilli. The detection rate of Methicillin-resistant Staphylococcus aureus was 34.2%, and no isolates of Staphylococci resistant to vancomycin and linezolid were found. The detection rates of ESBLs-producing bacteria in E. coli and K. pneumonia were 39.5% and 25.8%, respectively. All the enterobacteriaceae isolated were found to be sensitive to Carbapenems. The resistance rates of Pseudomonas aeruginosa to piperacillin/subacta, meropenem and levofloxacin were 22.8%, 24.4% and 27.7%, respectively. The resistance rates of Acinetobacter baumannii to meropenem and imipenem were 22.7% and 54.5%, respectively. The resistance rates of Burkholderia cepacia to levofloxacin, eropenem and SMZ/TMP were 2.3%, 9.1% and 9.1%, respectively. Conclusion Gram-negative bacteria were the main clinical isolates in the People’s Hospital of Hainan Province in 2010, mainly Pseudomonas aeruginosa. The resistance rate of Enterobacteriaceae to Carbapenems was the lowest. A regular detection of bacterial drug resistance is urgently needed for the rational use of antimicrobial agents.
Keywords:Bacterial drug resistance  Antimicrobial agents  Gram-positive cocci
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