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CA-125在先兆流产、难免流产、稽留流产中的表达及其临床意义
引用本文:姬超,张书艳,宋芳霞,买苗.CA-125在先兆流产、难免流产、稽留流产中的表达及其临床意义[J].海南医学,2016(18):2995-2997.
作者姓名:姬超  张书艳  宋芳霞  买苗
作者单位:陕西省第二人民医院妇产科,陕西 西安,710005
基金项目:陕西省科学技术研究发展计划项目(编号2012K13-31)
摘    要:目的:探讨先兆流产、难免流产、稽留流产患者CA-125的表达及其对预后的判断价值。方法选择2013年3月至2015年3月我院妇产科接诊保胎治疗的120例患者进行研究,根据妊娠结局分为正常对照组48例,流产观察组72例。检测两组患者的CA-125表达情况,并进行对比分析。结果流产观察组患者CA-125的表达为(56.33±11.22) kU/L,明显高于对照组的(16.18±7.88) kU/L,差异具有显著统计学意义(P<0.01);CA-125表达水平伴随着流产严重程度的增加而增高,CA-125表达水平先兆流产为(49.93±8.99) kU/L,难免流产为(52.46±9.78) kU/L,稽留流产为(62.33±10.24) kU/L,其中,先兆流产与难免流产患者,难免流产与稽留流产患者之间的CA-125表达水平比较差异均无统计学意义(P>0.05),而先兆流产与稽留流产患者CA-125表达水平比较差异则具有统计学意义(P<0.05)。结论先兆流产、难免流产、稽留流产患者CA-125的表达较正常妊娠妇女高,CA-125表达水平随着流产的严重程度逐渐升高,这对患者病情的诊治具有一定的指导作用。

关 键 词:CA-125  先兆流产  难免流产  稽留流产  应用价值

Expression of CA-125 in threatened abortion,inevitable abortion,missed abortion and its clinical significance
Abstract:Objective To investigate the expression of carbohydrate antigen 125 (CA-125) and its prognostic value in patients with threatened abortion, inevitable abortion, missed abortion. Methods A total of 120 patients who received tocolytic therapy in Department of Gynaecology and Obstetrics in our hospital from March 2013 to March 2015 were selected as subjects, which were divided into normal control group (n=48), abortion observation group (n=72) ac-cording to the pregnancy outcome. The expression of CA-125 in two groups were detected, and the comparative analysis was performed. Results The expression of CA-125 of patients in abortion observation group was (56.33±11.22) kU/L, which was significantly higher than that in control group of (16.18±7.88) kU/L, with statistically significant differ-ence (P<0.01). The expression level of CA-125 was increased with the severity of the abortion, and the expression level of CA-125 was (49.93±8.99) kU/L for threatened abortion, (52.46±9.78) kU/L for inevitable abortion, (62.33± 10.24) kU/L for missed abortion. Among them, the expression levels of CA-125 showed no significant difference be-tween threatened abortion and inevitable abortion, inevitable abortion and missed abortion (P>0.05). The expression levels of CA-125 showed statistically significant difference between threatened abortion and missed abortion (P<0.05). Conclusion CA-125 expression level of patients with threatened abortion, inevitable abortion, missed abortion are significantly higher than the normal pregnancy women. CA-125 expression level gradually increased with the severi-ty of abortion, which has a certain guiding role in the diagnosis and treatment of the patient's condition.
Keywords:Carbohydrate antigen 125 (CA-125)  Threatened abortion  Inevitable abortion  Missed abortion  Application value
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