| 海南黎族哮喘ORMDL3基因多态性研究 |
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| 引用本文： | 丁毅鹏,何海武,石慧芳,林莉,陈山,姚红霞.海南黎族哮喘ORMDL3基因多态性研究[J].海南医学,2012,23(11):1-2. |
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| 作者姓名： | 丁毅鹏 何海武 石慧芳 林莉 陈山 姚红霞 |
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| 作者单位： | 丁毅鹏 (海南省人民医院急救中心,海南海口,570311) ； 何海武 (海南省农垦总医院,海南海口,570311) ； 石慧芳 (海南省农垦总医院,海南海口,570311) ； 林莉 (海南省农垦总医院,海南海口,570311) ； 陈山 (海南省农垦总医院,海南海口,570311) ； 姚红霞 (海南省人民医院急救中心,海南海口,570311) ； |
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| 基金项目： | 海南省自然科学基金资助项目 |
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| 摘 要： | 目的探讨海南黎族哮喘与ORMDL3基因多态性的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)等方法对120例黎族哮喘患者ORMDL3基因多态性进行观察,并与150例正常对照组进行对比。结果哮喘组rs7216389位点TT型基因与对照组比较差异有统计学意义(P<0.05);哮喘组rs11650680位点TT型和CC型与对照组比较差异有统计学意义(P<0.05)。结论 ORMDL3基因多态性变化可能与黎族哮喘患者发病有一定的相关性。
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| 关 键 词： | ORMDL3 哮喘 黎族 基因多态性 |
Genetic polymorphism of ORMDL3 gene in patients with asthma in Li nationality of Hainan province |
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| DING Yi-peng,HE Hai-wu,SHI Hui-fang,LIN Li,CHEN Shan,YAO Hong-xia.Genetic polymorphism of ORMDL3 gene in patients with asthma in Li nationality of Hainan province[J].Hainan Medical Journal,2012,23(11):1-2. |
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| Authors: | DING Yi-peng HE Hai-wu SHI Hui-fang LIN Li CHEN Shan YAO Hong-xia |
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| Institution: | 1 . 1. Department of Emergency, People’s Hospital of Hainan Province, Haikou 570102, Hainan, CHINA; 2. Hainan Provincial Hospital of General Bureau of Agriculture, Haikou 570311, Hainan, CHINA |
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| Abstract: | Objective To explore the relationship between the genetic polymorphism of ORMDL3 gene and asthma in Li Nationality of Hainan province. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RLFP) was used to detect the genetic polymorphism of ORMDL3 gene in 120 patients with asthma in Li Nationality (the asthma group) and in 150 normal individuals (the control group). Results There was statistically significant difference in TT gene of rs7216389, TT and CC gene of rs11650608 between the asthma group and the control group. Conclusion The genetic polymorphism of ORDL3 gene showed a certain correlation with the asthma of Li nationality. |
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| Keywords: | ORMDL3 Asthma Li nationality Genetic polymorphism |
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