| 原发性无精子症病人的细胞遗传学分析 |
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| 引用本文： | 李强,孙玉丽,孙玉萍,傅秀艳,刘忠强,王沛涛.原发性无精子症病人的细胞遗传学分析[J].齐鲁医学杂志,2005,20(1):33-34,36. |
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| 作者姓名： | 李强 孙玉丽 孙玉萍 傅秀艳 刘忠强 王沛涛 |
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| 作者单位： | 1. 青岛大学医学院附属医院生殖医学中心,山东,青岛,266003
2. 文登市界石镇卫生院检验科 |
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| 摘 要： | ①目的 探讨无精子症病人的细胞遗传学效应。②方法 采用外周血培养方法对57例原发性无精子症病人进行染色体核型分析。③结果 检出染色体核型异常病人23例．均涉及性染色体。最多的为47．XXY共17例，检出率为29．83％,占异常核型的73．91％。其次为大Y染色体4例．检出率为7．02％,占异常核型的17．39％。46，XY／47，XXY和47，XYY各1例，检出率为1．75％，占异常核型的4．35％。④结论 性染色体异常是原发性无精子症发生的根本原因之一。
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| 关 键 词： | 少精液症 性染色体 染色体显带 |
| 文章编号： | 1008-0341(2005)01-0033-03 |
CYTOGENETICAL ANALYSIS OF PATIENTS WITH PRIMARY AZOOSPERMIA |
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| LI Qiang,SUN Yu-li,SUN Yu-ping,et al.CYTOGENETICAL ANALYSIS OF PATIENTS WITH PRIMARY AZOOSPERMIA[J].Medical Journal of Qilu,2005,20(1):33-34,36. |
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| Authors: | LI Qiang SUN Yu-li SUN Yu-ping |
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| Abstract: | Objective To study the cytogenetical effect of the patients with azoospermia. Methods Using the technique of peripheral blood culture, the chromosome karyotype of 57 patients with azoospermia was analyzed. Results Abnormal chromosome karyotype(ACK) was detected in 23 patients, sex chromosomes were involved in all these cases, the most were 47,XXY, 17 cases, which accounted for 29.83% of patients studied and 73.91% of those with ACK ; then were big Y chromosome, four cases, accounting for 7.02% of patients studied and 17.39% of those with ACK: 46,XY/47,XXY and 47,XXY, one case for each type. Conclusion The sex chromosome abnormality is one of the major causes of primary azoospermia. |
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| Keywords: | oligospermia sex chromosomes chromosome banding |
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