| HPV16E6和E7基因序列多态性与宫颈癌临床病理特征相关性 |
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| 引用本文： | 王玉婷,王言奎,赵成琳.HPV16E6和E7基因序列多态性与宫颈癌临床病理特征相关性[J].齐鲁医学杂志,2011,26(4):308-310,313. |
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| 作者姓名： | 王玉婷 王言奎 赵成琳 |
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| 作者单位： | 青岛大学医学院附属医院妇产科,山东青岛,266003 |
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| 摘 要： | 目的 探讨宫颈癌人乳头瘤病毒16型(HPV16)E6和E7转化基因序列多态性,及其与宫颈癌临床病理特征的相关性.方法 从77例宫颈癌组织中筛选出51例HPV16阳性标本,扩增E6及E7基因,PCR产物进行序列测定.应用DNAStar生物软件进行核苷酸和氨基酸序列的分析.结果 宫颈癌组织中HPV16 E6共测得6个突变位...
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| 关 键 词： | 宫颈肿瘤 人乳头瘤病毒16 E6基因 E7基因 多态性 单核苷酸 |
CORELATION BETWEEN THE POLYMORPHISM OF E6 AND E7 ONCOGENE OF HUMAN PAPILLOMAVIRUS TYPE 16 AND THE PATHOLOGICAL FEATURES OF CERVICAL CANCER |
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| WANG YU-TING,WANG YAN-KUI,ZHAO CHENG-LIN.CORELATION BETWEEN THE POLYMORPHISM OF E6 AND E7 ONCOGENE OF HUMAN PAPILLOMAVIRUS TYPE 16 AND THE PATHOLOGICAL FEATURES OF CERVICAL CANCER[J].Medical Journal of Qilu,2011,26(4):308-310,313. |
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| Authors: | WANG YU-TING WANG YAN-KUI ZHAO CHENG-LIN |
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| Institution: | WANG YU-TING,WANG YAN-KUI,ZHAO CHENG-LIN(Department of Gynecology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
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| Abstract: | Objective To investigate the polymorphism of HPV16 transforming gene E6 and E7 and its relationship with the pathological features of patients with cervical cancer. Methods Fifty-one HPV16-positive samples were screened form tissues of 77 cases of cervical cancer,E6 and E7 genes were amplified,and sequence analysis was done for PCR products. ResultsSix mutable points of HPV16 E6 gene were identified,which were missense mutation;the most frequently seen mutable point was T178G/A,with the mutation frequency o... |
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| Keywords: | uterine cervical neoplasms human papillomavirus 16 E6 gene E7 gene polymorphism single nucleotide |
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