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冠心病病人血浆细胞黏附分子-1水平的变化
引用本文:田景惠,刘成玉,李冬,刘文东.冠心病病人血浆细胞黏附分子-1水平的变化[J].齐鲁医学杂志,2006,21(6):479-480,484.
作者姓名:田景惠  刘成玉  李冬  刘文东
作者单位:1. 泰山医学院医学检验系,山东,泰安271000
2. 青岛大学医学院诊断学教研室
3. 潍坊医学院附属医院检验科
摘    要:目的观察冠心病(CHD)病人血浆细胞间黏附分子1水平的变化,并探讨其与冠心病活动性之间的关系。方法采用酶联免疫吸附(ELISA)法,检测了60例CHI)病人血浆可溶性细胞间黏附分子-1(sICAM-1)的水平,并与健康对照组进行比较。结果CHD病人血浆sICAM-1水平高于对照组(t=7.136,P〈0.01);且急性心肌梗死(AMI)病人显著高于陈旧性心肌梗死病人及稳定型心绞痛(SA)病人(t=4.329、5.635,P〈0.01),不稳定型心绞痛(UAP)病人高于SA病人(t=3.666,P〈0.01)。结论CHD病人sICAM-1水平明显高于正常对照组,且在一定程度上反映了病情的严重程度。

关 键 词:冠状动脉疾病  细胞黏附分子  酶联免疫吸附测定
文章编号:1008-0341(2006)06-0479-03
收稿时间:2005-10-08
修稿时间:2005-10-082006-02-10

CHANGES OF INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CORONARY HEART DISEASE
TIAN JING-HUI, LIUCHENG-YU, LIDONG, et al.CHANGES OF INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CORONARY HEART DISEASE[J].Medical Journal of Qilu,2006,21(6):479-480,484.
Authors:TIAN JING-HUI  LIUCHENG-YU  LIDONG  
Institution:Department of Medical Laboratory, Taishan Medical College, Taian 271000, China
Abstract:ObjectiveTo explore the changes of intercellular adhesion molecule-1(ICAM-1) in patients with coronary heart disease(CHD) and to evaluate its clinical relation to CHD.MethodsPlasma ICAM-1 was detected by enzyme-linked immunosorbent assay(ELISA) in 60 patients with CHD.The results were compared with those of the healthy subjects.Results(Plasma sICAM-1) was significantly elevated in patients with CHD and differed significantly from that of the control group(t=(7.136),P<0.01).The sICAM-1 in patients with acute myocardial infarction(AMI) was elevated more significantly than in old myocardial infarction(OMI) and stable angina(SA)(t=4.329,5.635;P<0.01).The level of sICAM-1 in patients with UAP was elevated more significantly than that in SA(t=3.666,P<0.01).ConclusionThe level of sICAM-1 in patients with coronary heart disease is significantly higher than that of the healthy control,which reflects some degree of severity of the disease.
Keywords:coronary artery disease  cell adhesion molecules  enzyme-linked immunosorbent assay
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