| 大豆异黄酮对脑缺血再灌注大鼠海马神经再生的影响 |
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| 作者姓名： | 龙军 张良 袁冬平 梁涛 周静 |
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| 作者单位： | 1. 南京中医药大学药学院,江苏,南京,210046
2. 江苏省中药药效与安全性评价重点实验室,江苏,南京,210029 |
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| 基金项目： | 南京中医药大学青年自然科学基金(07XZR07); 江苏省重点实验室开放课题资助项目(P09005) |
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| 摘 要： | 目的 观察大豆异黄酮对脑缺血再灌注大鼠海马神经再生的影响.方法 线栓法建立大鼠脑缺血再灌注模型,分别给予大豆异黄酮(SI)、7-硝基吲哚(7-NI)或联合给药(SI+7-NI),BrdU免疫荧光法标记新生海马神经细胞,免疫组化法检测海马区ONOO-的反应产物硝基酪氨酸(NT).结果 SI组、7-NI组和SI+7-NI组...
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| 关 键 词： | 大豆异黄酮 脑缺血再灌注 海马 神经再生 |
| 收稿时间： | 2010/6/10 0:00:00 |
| 修稿时间： | 2010/7/20 0:00:00 |
Effects of Soy Isoflavones on the Hippocampus Neurogenesis of Rats with Cerebral Ischemia and Reperfusion |
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| Authors: | LONG Jun ZHANG Liang YUAN Dong-ping LIANG Tao ZHOU Jing |
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| Institution: | LONG Jun 1,ZHANG Liang1,YUAN Dong-ping1,LIANG Tao1,ZHOU Jing2 (1.School of Pharmacy of Nanjing University of Chinese Medicine,Nanjing,210046,China,2.Key Labortory of Efficacy and Safety Evaluation of TCM,210029,China) |
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| Abstract: | OBJECTIVE To observe the effect of soy isoflavones on the hippocampus neurogenesis of rats with cerebral ischemia and reperfusion.METHODS Models of rats with cerebral ischemia and reperfusion were built by the method of middle cerebral artery occlusion,which were treated with soy isoflavones(SI),7-Nitroindole(7-NI) or coadministration of SI and 7-NI(SI+7-NI),respectively.Then neonatal hippocampus nerve cells were labeled with BrdU by immunofluorescence,and the nitrotyrosine(NT);and the production of ONOO-we... |
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| Keywords: | soy isoflavones cerebral ischemia and reperfusion hippocampus neurogenesis |
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