天然黄酮类化合物对芳香烃受体的调控作用研究进展

黄酮类成分广泛存在于植物、中草药中，具有多种药理学活性，近年来的研究表明，它可以通过调控多种信号通路发挥其抗炎、抗氧化、化学预防等作用。笔者聚焦在药物代谢、免疫调节、化学预防中具有重要作用的芳香烃受体，在系统综述芳香烃受体功能及调控模式基础上，总结了不同黄酮类化合物对芳香烃受体的激动或拮抗作用，并对常见黄酮成分通过芳香烃受体发挥其抗肿瘤、抗溃疡性结肠炎、抗特异性皮炎的独特作用机制进行了介绍，并展望了黄酮类化合物在上述疾病治疗中潜在前景和局限性。 

Recent Progress of Natural Flavonoids as Ligand on Aryl Hydrocarbon Receptor

Flavonoids are widely existed in plants and herbs, which have a variety of pharmacological activities. Recent studies have shown that they can exert anti-inflammatory, antioxidant, and chemopreventive effects by regulating various signaling pathways. In this paper, we focused on the aryl hydrocarbon receptor, which plays an important role in drug metabolism, immunomodulation, and chemoprevention. After a systematic review of the functions and regulation modes of aryl hydrocarbon receptor, we summarized the agonistic or antagonistic effects of different flavonoids on aryl hydrocarbon receptor and elaborated their anti-tumor, anti-ulcerative colitis, and anti-atopic dermatitis effects by activating aryl hydrocarbon receptor through unique mechanisms. Furthermore, the potential prospects and limitations of flavonoids in the treatment of the above diseases were also presented.