癌毒病机的生物学基础探讨

肿瘤微环境是与肿瘤侵袭、转移密不可分的局部内环境，肿瘤生物学研究的最新进展凸显了肿瘤细胞来源外泌体在调控肿瘤微环境中的重要地位。创建中医肿瘤癌毒病机理论，提出癌毒是肿瘤发生、发展的关键病机，肿瘤微环境可能是癌毒病机理论的生物学基础。通过比较癌毒与肿瘤细胞来源外泌体的产生、致病特性与致病机制，认为癌毒与肿瘤细胞来源外泌体密切相关，肿瘤细胞来源外泌体可能是癌毒病机的生物学基础，对进一步揭示癌毒病机理论的科学内涵具有重要意义。 

Discussion on Biological Basis of Cancer Toxin Pathogenesis

Tumor microenvironment is a local environment closely related to tumor cell proliferation and metastasis， recent advances in tumor biology research emphasize the important role of tumor cell-derived exosome in the regulation of tumor microenvironment. It is suggested that cancer toxin is the key pathogenesis of tumor occurrence and development， and tumor microenvironment may be the biological basis of cancer poison pathogenesis theory. By comparing the generation， pathogenic characteristics and pathogenic mechanism of cancer toxin and tumor cell-derived exosome， it is believed that cancer toxin is closely related to tumor cell-derived exosome， which may be the biological basis of cancer toxin and pathogenesis. It is of great significance to further revealing the scientific connotation of cancer virus pathogenesis theory.