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隆突性皮肤纤维肉瘤临床病理分析
引用本文:宦大为,王翠芳,李铭钟,许之屏. 隆突性皮肤纤维肉瘤临床病理分析[J]. 沈阳医学院学报, 2003, 5(1): 29-31
作者姓名:宦大为  王翠芳  李铭钟  许之屏
作者单位:1. 沈阳医学院附属中心医院病理科,辽宁,沈阳,110024
2. 沈阳市第五人民医院病理科
基金项目:沈阳市科委立项课题 ( 984935 0 42 0 )
摘    要:目的:探讨隆突性皮肤纤维肉瘤(DFSP)的临床病理特点、组织分化及鉴别诊断。方法:对24例DFSP进行常规HE染色辅以免疫组织化学染色。结果:24例DFSP均可见到席纹状结构(storiform),但此结构不是DFSP所特有。镜下还可见到间质黏液变性或胞浆含有色素或呈纤维肉瘤排列区域等多种结构的特点。其免疫组织化学染色Vimentin100%阳性,AACT7例阳性占29.1%(7/24),CD34阳性91.7%(22/24)。VEGF阳性占75%(18/24)。结论:DFSP起源于真皮原始间叶细胞,可向多方向分化,所以组织学上可分出多种亚型,其诊断、预后有所不同。常规HE诊断DFSP,联合检测CD34和VEGF具有重要意义。

关 键 词:隆突性皮肤纤维肉瘤 免疫组织化学 组织分化 临床病理学
文章编号:1008-2344(2003)01-0029-03
修稿时间:2002-08-26

Clinicopathological Analysis of Dermatofibrosarcoma Protuberans
HUAN Da-wei ,WANG Cui-fang ,LI Ming-zhong ,XU Zhi-ping. Clinicopathological Analysis of Dermatofibrosarcoma Protuberans[J]. Journal of Shenyang Medical College, 2003, 5(1): 29-31
Authors:HUAN Da-wei   WANG Cui-fang   LI Ming-zhong   XU Zhi-ping
Affiliation:HUAN Da-wei 1,WANG Cui-fang 1,LI Ming-zhong 1,XU Zhi-ping 2
Abstract:Objective: To investigate the clinicopathological characteristics, differentiation and differential diagnosis of dermatofibrosarcoma protuberans (DFSP). Methods: HE and immunohistochemistry were used to analyze 24 cases with DFSP. Results: The storiform was observated in all DFSP and other spindal cell tumors. But it was not specialized in DFSP. The tumor comprised a variably proportional mixture of fibrous and myxoid areas or pigmented or fibrosarcomatous change. Positive rates of immunostainings were: 100% in Vimentin , 29.1% in AACT, 91.7% in CD34 and 75% in VEGF respectively in cases. Conclusions: DFSP originates from the primary mesenchyme cell of derma and differentiated into various mesenchyme tissues. So the tumor may be classifed subclassfication on histologic features. The diagnosis and prognosis of the subclassification of DFSP are different. The HE staining may diagnose the tumor. Immunohistochemistry staining of CD34 and VEGF may play an important role in the differential diagnosis.
Keywords:dermatofibrosarcoma protuberans  immunohistochemistry  differentiation  clinicopathology
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