宫颈癌组织中p-ERK和TGF—β1蛋白的表达及其相关性 |
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引用本文: | 陈文殊,吕杰强,徐峰,薛海燕,沈旭娜,冯泽蛟.宫颈癌组织中p-ERK和TGF—β1蛋白的表达及其相关性[J].浙江医学,2010,32(8):1177-1179,1283. |
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作者姓名: | 陈文殊 吕杰强 徐峰 薛海燕 沈旭娜 冯泽蛟 |
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作者单位: | 1. 温州医学院定理临床学院妇产科,325000 2. 温州医学院附属第二医院妇产科 |
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摘 要: | 目的探讨磷酸化的细胞外信号调节激酶(P—ERK)和转化生长因子-β1(TGF-β1)蛋白在宫颈癌组织中的表达及其相关性。方法采用免疫组织化学SP法检测P~ERK和TGF-β1蛋白在宫颈癌(宫颈癌组,n=50)、宫颈上皮内瘤变(CIN组,n=25)和正常宫颈组织(正常宫颈组,n=25)中的表达情况,并分析P—ERK和TGF-β1的相关性。结果P—ERK蛋白在宫颈癌组、CIN组和正常宫颈组中的阳性表达率分别为84%、48%、20%,宫颈癌组与CIN组、正常宫颈组比较差异有显著统计学意义(均P〈O.01),后两组比较差异有统计学意义(P〈O05)。TGF-β1蛋白在宫颈癌组、CIN组和正常宫颈组中的阳性表达率分别为86%、44%、12%,宫颈癌组与CIN组、正常宫颈组比较差异均有显著统计学意义(P〈0.01),后两组比较差异有统计学意义(P〈O.05)。P—ERK和TGF-β1蛋白在宫颈癌组织中的表达呈显著正相关(r=0.457,P〈0.01)。结论P—ERK、TGF-β1与宫颈癌发生有关,两者在宫颈癌组织中的表达呈明显正相关。
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关 键 词: | 宫颈癌 细胞外信号调节激酶 转化生长因子-β1 免疫组织化学 |
Expression of external-signal regulated kinase and TGF-β1 protein in human cervical carcinoma and their relationship |
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Institution: | CHEN Wenshu, LV Jieqiang, XU Feng, et al. (Department of Obstetrics and Gynecology, The Ding-Li Clinical Institute of Wenzhou Medical College, Wenzhou 325000, China) |
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Abstract: | Objective To investigate the expression of external-signal regulated kinase (ERK)and transfer growth factor-β1 (TGF-β1) in human cervical carcinoma and their relationship. Methods The expressions of ERK and TGF-β1 proteins were detected by immunohistochemical technique in 50 cases of cervical carcinoma, 25 cases of cervical intraepithelial neoplasia (CIN) and 25 samples of normal cervical tissue; and their clinical significance was analyzed. Results The positive rates of ERK and TGF-β1 in cervical carcinoma, CIN and normal cervical tissue were 84% and 86%; 48% and 44%; 20% and 12% respectively. There were significant differences in ERK and TGF-β1 expressions between cervical carcinoma and CIN or normal cervical epithelium (P〈0.01). There were also significant differences in ERK and TGF-β1 expressions between CIN and normal cervical epithelium(P〈0.05 ), The expression of ERK was positively correlated with TGF-β1 in human cervical carcinoma (r=0.457, P〈0.01 ). Conclusion ERK and TGF- β1 are highly expressed in cervical cancer and correlated with each other; both proteins may be involved in the pathogenesis of cervical carcinoma. |
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Keywords: | Cervix neoplasms Extenal-signal regulated kinase Transfer growth factor-β1 Immunohistochemistry |
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